| Aurora激酶及其抑制剂的研究进展 |
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| 引用本文： | 朱海静,焦宇. Aurora激酶及其抑制剂的研究进展[J]. 中国现代应用药学, 2014, 31(10): 1288-1296 |
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| 作者姓名： | 朱海静 焦宇 |
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| 作者单位： | 解放军第二炮兵总医院，北京 100088;中国药科大学有机化学教研室，南京 211198 |
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| 摘 要： | 目的 从结构出发介绍Aurora激酶及其抑制剂的研究进展。方法 总结 Aurora激酶抑制剂骨架特征和结合模式，以及进入临床的Aurora激酶抑制剂的研究进展。结果和结论 Aurora激酶家族是肿瘤治疗的一个新兴靶标。腺嘌呤骨架可能是设计高活性Aurora激酶抑制剂的重要母核。
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| 关 键 词： | Aurora激酶；抑制剂；结合模式；抗肿瘤 |
| 收稿时间： | 2013-11-08 |
| 修稿时间： | 2014-04-17 |
Progress of Aurora Kinase and Its Inhibitors |
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| ZHU Haijing and JIAO Yu. Progress of Aurora Kinase and Its Inhibitors[J]. The Chinese Journal of Modern Applied Pharmacy, 2014, 31(10): 1288-1296 |
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| Authors: | ZHU Haijing and JIAO Yu |
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| Abstract: | OBJECTIVE To introduce the research progress of Aurora kinase and its inhibitors based on their structures. METHODS To summarize the chemical scaffold , the common binding modes, and the clinical progress of Aurora kinase inhibitors. RESULTS & CONCLUSION The Aurora kinase had emerged as an attractive target for cancer therapies. The adenosine mimic scaffolds could be used for further study to design addtional potential inhibitors of Aurora with high inhibitory activity. |
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| Keywords: | Aurora kinase inhibitor binding mode anti-tumor |
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