| 清开灵注射液对SHP_(sp)出血性中风海马区兴奋性氨基酸含量的影响 |
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| 引用本文： | 蒋玉凤,朱陵群,黄启福,李克玲,邹丽琰,贾旭,严京,李伯光.清开灵注射液对SHP_(sp)出血性中风海马区兴奋性氨基酸含量的影响[J].中国中医急症,1997(5). |
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| 作者姓名： | 蒋玉凤 朱陵群 黄启福 李克玲 邹丽琰 贾旭 严京 李伯光 |
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| 作者单位： | 北京中医药大学!北京100029 |
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| 摘 要： | 本研究采用年中易感型自发性高血压大鼠（SHPsp）.观察了清开灵（QKL）注射液对出血性中风海马区兴奋性氨基酸（EAA）含量的影响，以及神经元密度和超微结构的改变。结果显示：QKL能使海马区EAA、谷氨酸、天门冬氨酸明显降低（P＜0．01）；海马CA1区神经元损伤轻,脱失减少,神经元密度计数显著升高（P＜0．01）；超微结构显示，QKL能使出血性中风造成的脑组织变性、坏死、水肿得到改善。上述结果提示，QKL能降低SHPsp出血性中风EAA的释放,起到保护神经细胞的作用。
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| 关 键 词： | 脑出血 中风 海马区 SHP_(sp) EAA 超微结构 清开灵注射液 |
The Effect of Qing Kai Ling Injection on Hippocampal Excitatory Amino Acid in Hemorrhagic Apoplexy of SHR_(sp) |
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| Jiang Yufeng,Zu Huang Qifu.et al..The Effect of Qing Kai Ling Injection on Hippocampal Excitatory Amino Acid in Hemorrhagic Apoplexy of SHR_(sp)[J].Journal of Emergency in Traditional Chinese Medicine,1997(5). |
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| Authors: | Jiang Yufeng Zu Huang Qifu |
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| Institution: | Beijing University of Traditional Chinese Medicine |
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| Abstract: | This study adopted strok prone spontaneously hypertensive rats (SHRsp )as subjects to observe the effect of Qing Kai Ling (QKL ) injection on the concentration of excitatory amino acid (EAA ) in hippocampal sector,neuronal density and ultrastructural changes in homorrhagic apoplexy. The exprimental results showed that QKL markedly reduced the concentration of EAA glutamate and aspartate in hippocampal sector (P < 0.01 ). decreased the injury of neuron and markedly increased neuronal density in hippocampal CA1 sector (P<0.01 ). Ultrastructural observation showed that QKL improved the denaturation. necrosis and edema of brain tissue. It was suggested that the protective effect on nerve cells might be associated with a drop of EAA release. |
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| Keywords: | Encephalorrhagia Apoplexy Hippocampus SHR_(sp) Excitatory amino acid Ultrastructure Qing Kai Ling injection |
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