路氏润燥汤治疗干燥综合征患者眼干症状临床效果分析

目的：探讨路氏润燥汤结合西医治疗原发性干燥综合征( pSS)患者眼干症状的效果。方法回顾性分析2012年7月—2015年7月71例气阴两虚型pSS合并眼干症状患者的临床资料，根据治疗方案分为观察组39例和对照组32例。对照组给予硫酸羟氯喹片口服，观察组在对照组基础上给予路氏润燥汤煎服。评估临床疗效，记录治疗前后眼干评分、眼干VAS评分及泪液流率，检测类风湿因子( RF)、免疫球蛋白G( lgG)、血沉( ESR)、抗SSA和抗SSB抗体。结果观察组治疗有效率显著高于对照组(P<0．05)；观察组治疗后眼干症状评分、眼干VAS评分及RF、lgG水平明显低于对照组(P<0．05)。结论路氏润燥汤结合西医治疗能有效缓解pSS患者眼干症状，疗效确切。

Clinical Effect of Lu's Runzao Decoction in Treatment of Dry Eye Symptoms in Patients with Sjogren's Syndrome

Objective To investigate effect of Lu's Runzao Decoction combined with western medicine in treat-ment of dry eye symptoms in patients with primary Sjogren's syndrome ( pSS) . Methods Clinical data of pSS 71 patients with Qi-yin deficiency type complicated by dry eye symptoms admitted between July 2012 and July 2015 was retrospec-tively analyzed, and the patients were divided into observation group (n=39) and control group (n=32) according to treatment methods. Control group was treated with Hydroxychloroquine Sulfate Tablets orally, and observation group was treated with Lu's Runzao Decoction based on the treatment in control group. In two groups, curative effects were evalua-ted, and dry eye score, visual analogue scales ( VAS) score of dry eye and flow rate of tears were recorded before and af-ter treatment, and levels of rheumatoid factors ( RF) , immunoglobulin G ( IgG) , erythrocyte sedimentation rate ( ESR) , anti-SSA and anti-SSB antibodies were detected. Results Compared with those in control group, in observation group, effective rate of treatment was higher (P<0. 05);dry eye score, VAS score of dry eye RF and IgG levels after treatment were significantly lower (P<0. 05). Conclusion Lu's Runzao Decoction combined with western medicine can effective-ly relieve dry eye symptoms of pSS patients with dry eye symptoms.