| 地龙粉剂对小鼠、大鼠与兔的镇痛解热作用 |
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| 引用本文： | 陈斌艳,张蕾,虞礼敏,王竞,王永铭.地龙粉剂对小鼠、大鼠与兔的镇痛解热作用[J].复旦学报(医学版),1996(3). |
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| 作者姓名： | 陈斌艳 张蕾 虞礼敏 王竞 王永铭 |
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| 作者单位： | 上海医科大学药学院药理学教研室 |
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| 摘 要： | 以扑热息痛为阳性对照药，用小鼠扭体法、大鼠甩尾法为镇痛模型，以内毒素致热兔为发热模型，研究中药地龙粉剂是否具有解热镇痛作用及其与扑热息痛合用是否有协同作用。结果：地龙粉剂有明显的镇痛作用，与扑热息痛合用有协同作用。地龙粉剂对内毒素致热兔有明显的解热作用，但与扑热息痛合用并无明显的协同作用。结论：地龙粉剂具有明显的解热镇痛作用。
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| 关 键 词： | 地龙粉剂 扑热息痛 解热镇痛作用 |
ANALGESIC AND ANTIPYRETIC ACTIVITIES OF DIRYU PULVIS IN MICE, RATS AND RABBITS |
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| Chen Binyan, Zhang Lei, Yu Liming, Wang Jiang, Wang Yongming.ANALGESIC AND ANTIPYRETIC ACTIVITIES OF DIRYU PULVIS IN MICE, RATS AND RABBITS[J].Fudan University Journal of Medical Sciences,1996(3). |
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| Authors: | Chen Binyan Zhang Lei Yu Liming Wang Jiang Wang Yongming |
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| Abstract: | PURPOSE To investigate whether diryu pulvis has any analgesic and antipyretic activities, or has any synergism in combination with paracetamol.METHODS Following testing models were used, mouse writhing and rat tail flick for analgesic activity, endotoxin induced pyrexia in rabbit for antipyretic activity.RESULTS diryu pulvis had analgesic and antipyretic activities. When diryu extract and paracetamol were used in combination, the synergism was certain in analgesic. However,there was no significant synergism in antipyretic activity.CONCLUSIONS diryu pulvis does have analgesic and antipyretic activities. |
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| Keywords: | diryu pulvis paracetamol analgesic and antipyretic activities |
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