放射性粒子植入联合酪氨酸激酶抑制剂治疗晚期非小细胞肺癌的远期疗效分析

目的 探究放射性粒子植入联合酪氨酸激酶抑制剂治疗晚期非小细胞肺癌的远期疗效.方法 选取晚期非小细胞肺癌患者(突变阳性且为ⅢB~Ⅳ期的不可通过手术方法切除)52例作为该研究的对象,分为观察组和对照组,观察组患者26例,行放射性粒子植入联合酪氨酸激酶抑制剂治疗,对照组26例,选择单药酪氨酸激酶抑制剂治疗,治疗结束后对不同组患者的临床治疗率、不良反应以及生存率进行比较和分析.结果 观察组局部控制率为92.31%,对照组局部控制率为65.38%,组间差异显著,具有统计学的意义(P＜0.05);两组患者的有效率组间比较无显著差异,无统计学意义(P＞0.05);两组患者不良反应发生率比较无显著差异,无统计学意义(P＜0.05),观察组患者出现1例Ⅲ度白细胞脱落,治疗后恢复正常,两组患者均无出现对其他脏器的功能损害;观察组患者的1年生存率为80.76%,对照组患者的1年生存率为61.54%,组间差异显著,具有统计学意义(P＜0.05);观察组患者2年生存率为65.38%,对照组患者的2年生存率为38.46%,组间差异显著,具有统计学意义(P＜0.05);观察组的无进展生存时间以及中位生存时间也长于对照组(P＜0.05).结论 酪氨酸激酶抑制剂联合植入放射性粒子治疗晚期的非小细胞肺癌疗效优于单药,是一种有效性高、安全性好的治疗方法,值得推广.

Long-term Efficacy of Radioactive Seed Implantation Combined with Tyrosine KinaseInhibitors in the Treatment of Advanced Non-small Cell Lung Cancer

Objective To explore the long-term effect of radioactive seed implantation combined with tyrosine kinase inhibitor in the treatment of advanced non-small cell lung cancer.Methods 52 cases of advanced non-small cell lung cancer patients(mutation positive and for stage ⅢB~Ⅳ cannot be surgically removed) were selected as research objects,they were divided into observation group and the control group,the observation group(n=26) were given radioactive particles implantation combined with tyrosine kinase inhibitor treatment,the control group(26 cases) were given choice of single drug of tyrosine kinase inhibitor treatment,after the end of treatment,the clinical treatment rates,adverse reactions and survival rates of different groups were compared and analyzed.Results The local control rate of the observation group was 92.31%,the local control rate of the control group was 65.38%,the difference between the 2 groups was significant,there had statistical significance(P＜0.05);The difference of the efficiency between the 2 groups was not significant,there had no statistical significance(P＞0.05);The difference of the incidences of adverse reactions between the 2 groups was not significant,there had no statistical significance(P＜0.05),the observation group had white blood cell shedding,after treatment returned to normal,the two groups had no functional damage to other organs;1-year survival rate of the observation group was 80.76%,1-year survival rate of the control group was 61.54%,the difference between the 2 groups was significant,there had statistical significance(P＜0.05);2-year survival rate of the observation group was 65.38%,2-year survival rate of the control group was 38.46%,the difference between the 2 groups was significant,there had statistical significance(P＜0.05).The progression free survival time and median survival time of the observation group were longer than those of the control group(P＜0.05).Conclusion The curative effect of radioactive seed implantation combined with tyrosine kinase inhibitor in the treatment of advanced non small cell lung cancer is better than that of single drug,it is an effective and safe treatment methods,so is worthy of promotion.