| PI3K/Akt/mTOR信号通路在上皮源性恶性肿瘤中的研究进展 |
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| 引用本文： | 张娟,徐丹,何黎,陈洪铎. PI3K/Akt/mTOR信号通路在上皮源性恶性肿瘤中的研究进展[J]. 现代肿瘤医学, 2017, 0(14): 2330-2333. DOI: 10.3969/j.issn.1672-4992.2017.14.038 |
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| 作者姓名： | 张娟 徐丹 何黎 陈洪铎 |
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| 作者单位： | 1. 昆明医科大学第一附属医院皮肤科,云南 昆明,650032;2. 中国医科大学附属第一医院皮肤科,辽宁 沈阳,110001 |
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| 基金项目： | 国家自然科学基金(81472540)，陈洪铎院士专家工作站(2013IC043) |
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| 摘 要： | 磷脂酰肌醇3-激酶/蛋白激酶B/哺乳类动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路不仅与细胞的增殖、存活及迁移密切相关,其与肿瘤的发生和发展也具有相关性.近年来,以该通路作为抗肿瘤治疗的靶点已成为研究的热点.本文就PI3K/Akt/mTOR信号通路在上皮来源恶性肿瘤活化、发生、发展中的作用,特别是皮肤鳞癌中的最新研究进展作一综述,并为皮肤肿瘤治疗及新药开发做一展望.
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| 关 键 词： | PI3K/Akt/mTOR 信号通路 上皮源性恶性肿瘤 鳞状细胞癌 日光性角化病 |
The research progress of PI3K/Akt/mTOR signaling pathway in epithelial malignant tumor |
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| Zhang Juan,Xu Dan,He Li,Chen Hongduo. The research progress of PI3K/Akt/mTOR signaling pathway in epithelial malignant tumor[J]. Journal of Modern Oncology, 2017, 0(14): 2330-2333. DOI: 10.3969/j.issn.1672-4992.2017.14.038 |
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| Authors: | Zhang Juan Xu Dan He Li Chen Hongduo |
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| Abstract: | Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR) signaling pathway is not only closely related to cell proliferation,survival,migration,it's also correlated with tumor occurrence and progression.In recent years,this pathway as a target of anti-tumor therapy has become a research hotspot.This paper reviews the function of PI3K/Akt/mTOR signaling pathway in activation,the occurrence and development of epithelial malignant tumor and summarizes the research progress,especially in skin squamous cell carcinomas,and makes a prospect for skin cancer treatment and new drugs development. |
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| Keywords: | PI3K/Akt/mTOR signaling pathways epithelial malignant tumor squamous cell carcinomas actinic keratosis |
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