The effect of regulation of high blood pressure on plasma endothelin-1 levels in blacks with hypertension |
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| Affiliation: | 1. Internal Medicine, Mercer University School of Medicine-Medical Center of Central Georgia, Macon, Georgia, USA;2. Department of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia.USA;1. Stockholm Environment Institute, Davis, CA, USA;2. Stockholm Environment Institute, Somerville, MA, USA;3. Ministry of Environment and Water (MMAyA), Bolivia;1. Ecosystems and Environment Research Programme, Department of Biological and Environmental Sciences, University of Helsinki, Niemenkatu 73, FI-15140 Lahti, Finland;2. Natural Resources Institute Finland, Horticulture Technologies, Itäinen Pitkäkatu 4, Turku, Finland;1. Renewable Energy Research Group, The Hong Kong Polytechnic University, Hong Kong, China;2. Key Laboratory of Renewable Energy Utilization Technologies in Buildings, Ministry of Education, Jinan, China;3. School of Thermal Energy Engineering, Shandong Jianzhu University, Jinan, China;1. Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Education and Research Department, São Pedro Psychiatric Hospital, Porto Alegre, Brazil;3. Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA;4. Department of Psychiatry, Jos University Teaching Hospital, Jos, Plateau State, Nigeria;5. General Psychiatry Trainee. Osaka Psychiatric Medical Center, Osaka, Japan;6. Section of Early Career Psychiatrist, Royal Australia and New Zealand College of Psychiatrists, Australia;7. Psychiatric Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro, Italy;8. Fidmag Research Foundation, Hermanas Hospitalarias, Barcelona, Spain;9. Hospital Benito Menni CASM, Hermanas Hospitalarias, Sant Boi de Llobregat, Spain |
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| Abstract: | ![]()
Plasma concentrations of immunoreactive endothelin-1 (irET-1) are significantly elevated in blacks with hypertension. In the present study, we investigated the effect of the regulation of high blood pressure on plasma irET-1 levels in black hypertensive individuals. After the initial blood samples were collected from 20 black patients with uncontrolled high blood pressure (Day 1), an intensive antihypertensive treatment was initiated, and the blood pressure and plasma irET-1 levels were monitored on days 2, 8, and 22. When the high blood pressure was brought under control with commonly used antihypertensive medications, plasma irET-1 concentrations dropped dramatically, suggesting that ET-1 concentrations rise as a consequence of high blood pressure in this study group. |
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