内质网应激与眼科疾病

内质网是蛋白质修饰、折叠和钙储存的场所。内质网中钙离子紊乱和未折叠蛋白质蓄积,可引发内质网应激,发生具有保护作用的未折叠蛋白反应。而长期过强的内质网应激可诱导细胞凋亡。许多眼科疾病的发生发展与内质网应激过程相关,例如：年龄相关性黄斑变性、视网膜色素变性、糖尿病视网膜病变、青光眼及白内障等。本文主要将近年来与内质网应激相关的眼科疾病的研究作一综述。

Endoplasmic reticulum stress and eye disease

Endoplasmic reticulum(ER) is a locus where proteins are modified,folded and calcium saved.The disorder of calcium iron and accumulation of unfolded protein can lead to ER stress and thus protective unfolded protein response ensure.But long-term strong ER stress will induce cell apoptosis.A lot of the eye diseases are correlated with ER stress,such as age-related macular degeneration,retinitis pigmentosa,diabetic retinopathy,glaucoma and cataract.This article mainly summarizes the current progress of the eye diseases associated with ER stress.