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| 人参皂苷Rd固体脂质纳米粒的制备 | |
| 引用本文： | 刘德育,罗德凤,叶建涛. 人参皂苷Rd固体脂质纳米粒的制备[J]. 中国医院药学杂志, 2010, 0(1) |
| 作者姓名： | 刘德育 罗德凤 叶建涛 |
| 作者单位： | 中山大学药学院; |
| 摘 要： | 目的:制备人参皂苷Rd固体脂质纳米粒,并考察其理化性质。方法:从旋转薄膜-超声分散法、乳化蒸发-低温固化法、高剪切乳化超声法和高压乳匀法中优选出制备方法;在脂质、表面活性剂等辅料和主药用量的单因素考察基础上,采用正交试验设计,确定最佳处方组成和制备工艺条件;用凝胶柱色谱和HPLC法测定包封率,透射电镜观察形态,激光粒径分析仪测定粒径和Zeta电位。结果:脂质、表面活性剂、助表面活性剂和主药的用量对Rd固体脂质纳米粒的粒径、Zeta电位和包封率均有不同程度的影响。高压乳匀法适合制备Rd固体脂质纳米粒。纳米粒表面呈圆整的球状,大小相近,分散均匀;平均粒径为(102.7±27.0)nm,Zeta电位为(-44.9±9.5)mV,包封率和载药量分别为(81.8±2.6)%和(6.37±0.21)%(n=3)。纳米粒稳定性良好,在4℃下保存4周后,粒径和包封率变化不明显。结论:高压乳匀法适合制备人参皂苷Rd固体脂质纳米粒,工艺稳定可行。 |
| 关 键 词： | 人参皂苷Rd 固体脂质纳米粒 制备 高压乳匀法 |
Study on preparation of ginsenoside-Rd solid lipid nanoparticles |
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| LIU De-yu,LUO De-feng,YE Jian-tao. Study on preparation of ginsenoside-Rd solid lipid nanoparticles[J]. Chinese Journal of Hospital Pharmacy, 2010, 0(1) | |
| Authors: | LIU De-yu LUO De-feng YE Jian-tao |
| Affiliation: | LIU De-yu,LUO De-feng,YE Jian-tao (School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangdong Guangzhou 510089,China) |
| Abstract: | OBJECTIVE To develop ginsenoside-Rd solid lipid nanoparticles(Rd-SLN) encapsulation.METHODS To optimize the technique of preparation,Rd-SLN was prepared by film-ultrasonic wave dissolving technique,emulsion evaporation and solidification,high shear homogenization and ultrasound,and high pressure homogenization,respectively.Based on the test of single factor,the optimized formulation of Rd-SLN was conveniently obtained by the L9(34) orthogonal methodology.The entrapment efficiency was determined by sephadex ... |
| Keywords: | ginsenoside-Rd solid lipid nanoparticles preparation high pressure homogenization |
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