重组人生长激素治疗男性更年期综合征的临床研究

目的:探讨重组人生长激素(rhGH)治疗男性更年期综合征的有效性和安全性,并探讨胰岛素样生长因子-1(IGF-1)和睾酮作为其疗效指标的特异性和敏感性。方法:40例40~75岁男性更年期综合征患者随机分为2组,每组20例,分别每周注射rhGH4IU(A组)和8IU(B组),治疗12周,随访12周,治疗期4、8、12周和治疗后12周进行伊斯坦布尔Bosphorus男性更年期自我评定表评分。治疗前后测定血清IGF-1、总睾酮(TT)及前列腺特异性抗原(PSA),用SPSS12.0软件对数据进行统计学分析。结果:A、B组治疗期的4、8、12周及随访期评分与筛选期相比差异均有非常显著性(P<0.01)。在同一治疗阶段A、B两组间相比差异均不显著(P>0.05)。治疗前后血清TT、PSA和前列腺体积无明显变化(P>0.05)。治疗后IGF-1水平高于治疗前水平和正常人群水平。rhGH治疗男性更年期综合征未见明显不良反应。结论:应用rhGH每周4IU,12周为1个疗程能有效治疗男性更年期综合征,IGF-1与治疗效果是平行的。成人短期小剂量应用rhGH安全性好,不良反应小。

Clinical Study of Recombinant Human Growth Hormone for Male Climacteric Syndrome

OBJECTIVE: To evaluate the effect and safety of the recombinant human growth hormone (rhGH) in the treatment of male climacteric syndrome and to investigate the specificity and sensitivity of insulin-like growth factor-1 (IGF-1) and serum total testosterone as the curative effect index. METHODS: Forty patients aged 40-75 with male climacteric syndrome were divided into two groups randomly and injected with rhGH 4 IU (Group A) or 8 IU (Group B). The patients were followed up for about 12 weeks after 12-week treatment and then asked the questions of the assessed index of male climacteric syndrome at the 4th, 8th and 12th week of the treatment and 12 weeks after the treatment. The serum IGF-1, total testosterone (TT) and prostatic specific antigen(PSA) were measured before and after the treatment. The data were analysed by the software of SPSS 12.0 for Windows. RESULTS: The scores of the 4th, 8th and 12th week and the follow-up significantly declined compared with the baseline (P < 0.01), but did not differ significantly between Groups A and B (P > 0.05). After the treatment, serum total testosterone, PSA and prostate volume had no obvious change (P > 0.05), and the IGF-1 level was markedly higher than the baseline and the normal public. No obvious side effect was found during the treatment and follow-up. CONCLUSION: Small dosage of rhGH(4 IU/week) for 12 weeks can effectively treat male climacteric syndrome. The value of IGF-1 was parallel with the treatment effects. Short-time and small-dosage treatment with rhGH is safe and has little side effect.