Two Lambert-Eaton Myasthenic Syndrome Patients with Ameliorated Activities of Daily Living Due to Cholinesterase Inhibitors |
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| Authors: | Hiroshi Yamasaki Naonobu Futamura Itaru Funakawa Nobuo Kohara Shunsuke Yoshimura Masakatsu Motomura |
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| Affiliation: | 1.Department of Neurology, National Hospital Organization Hyogo-Chuo National Hospital, Japan; 2.Department of Neurology, Kobe City Medical Center General Hospital, Japan; 3.Department of Neurology and Strokology, Nagasaki University Hospital, Japan; 4.Medical Engineering Course, Department of Engineering, The Faculty of Engineering, Nagasaki Institute of Applied Science, Japan |
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| Abstract: | ![]()
We herein report two P/Q-type voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS) patients who responded dramatically to cholinesterase inhibitors. Patient 1, a 76-year-old man, had small-cell lung cancer and developed LEMS during chemotherapy. When symptomatic treatment was started with pyridostigmine, gait disturbance was ameliorated, and his modified Rankin scale decreased from 4 points to 3 points. Patient 2, a 68-year-old man, had cancer-free LEMS. Distigmine bromide was very effective and ameliorated not only his gait disturbance but also autonomic symptoms, and his modified Rankin scale decreased from 2 points to 1 point. Cholinesterase inhibitors alone may be effective in a small portion of LEMS patients. |
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| Keywords: | Lambert-Eaton myasthenic syndrome (LEMS) treatment algorithm electrophysiological examination 3 4-diaminopyridine cholinesterase inhibitors |
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