| 蛋白精氨酸甲基转移酶5在急性髓系白血病中的研究进展 |
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| 引用本文： | 赵璐,王季石. 蛋白精氨酸甲基转移酶5在急性髓系白血病中的研究进展[J]. 现代肿瘤医学, 2021, 0(5): 892-895. DOI: 10.3969/j.issn.1672-4992.2021.05.039 |
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| 作者姓名： | 赵璐 王季石 |
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| 作者单位： | 1.贵州医科大学附属医院血液科,贵州省造血干细胞移植中心实验室,贵州 贵阳 550004;2.陆军军医大学第二附属医院血液科,重庆 400037 |
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| 基金项目： | 国家自然科学基金(编号:81960032)。 |
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| 摘 要： | 急性髓系白血病(acute myeloid leukemia,AML)是一种常见的恶性血液肿瘤.表观遗传学修饰可以通过转录后甲基化等方式在AML中发挥关键作用.蛋白精氨酸甲基转移酶5(protein arginine methyl-transferase 5,PRMT5)是一种Ⅱ型蛋白精氨酸甲基转移酶,可通过催化作用将...
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| 关 键 词： | 蛋白精氨酸甲基转移酶5 急性髓系白血病 蛋白精氨酸甲基化 |
Research progress of protein arginine methyltransferase 5 in acute myeloid leukemia |
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| ZHAO Lu,WANG Jishi. Research progress of protein arginine methyltransferase 5 in acute myeloid leukemia[J]. Journal of Modern Oncology, 2021, 0(5): 892-895. DOI: 10.3969/j.issn.1672-4992.2021.05.039 |
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| Authors: | ZHAO Lu WANG Jishi |
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| Affiliation: | 1.Department of Hematology,the Affiliated Hospital of Guizhou Medical University,Guizhou Guiyang 550004,China;2.Department of Hematology,Second Affiliated Hospital,Army Medical University,Chongqing 400037,China. |
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| Abstract: | Acute myeloid leukemia(AML) is a common malignant hematological tumor.Epigenetic modification can play a key role in the progress of AML through post-transcriptional methylation.Protein arginine methyltransferase 5(PRMT5) is a type Ⅱ protein arginine methyltransferase.Through catalysis,the methyl of S-adenosylmethionine could be transferred to the guanidine nitrogen atom of arginine to form methyl arginine and S-adenosylhomocysteine.In recent years,it has been found that PRMT5 could promote the occurrence and development of AML by regulating post-transcriptional methylation and mRNA splicing of tumor-related genes.This paper reviewed the research progress of PRMT5 in AML and summarized the therapeutic effect of PRMT5 inhibitors on AML. |
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| Keywords: | protein arginine methyltransferase 5 acute myeloid leukemia protein arginine methylation |
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