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达比加群酯联合替格瑞洛对老年心房颤动合并不稳定型心绞痛患者的治疗效果
引用本文:刘雅楠,李国杰. 达比加群酯联合替格瑞洛对老年心房颤动合并不稳定型心绞痛患者的治疗效果[J]. 中国实用医药, 2021, 0(6): 10-12
作者姓名:刘雅楠  李国杰
作者单位:内蒙古科技大学包头医学院第二附属医院心内科
摘    要:
目的 探讨在治疗老年心房颤动合并不稳定型心绞痛时使用达比加群酯联合替格瑞洛对其凝血功能及临床疗效的影响.方法 120例老年心房颤动合并不稳定型心绞痛患者,按照入院的先后顺序分成观察组和对照组,每组60例.对照组在常规治疗的基础上口服华法林、替格瑞洛进行治疗,观察组在常规治疗的基础上加用达比加群酯联合替格瑞洛进行治疗.比...

关 键 词:心房颤动  不稳定型心绞痛  达比加群酯  替格瑞洛  治疗效果

Effect of dabigatran etexilate combined with ticagrelor in the treatment of elderly patients with atrial fibrillation and unstable angina pectoris
LIU Ya-nan,LI Guo-jie. Effect of dabigatran etexilate combined with ticagrelor in the treatment of elderly patients with atrial fibrillation and unstable angina pectoris[J]. China Practical Medical, 2021, 0(6): 10-12
Authors:LIU Ya-nan  LI Guo-jie
Affiliation:(Department of Cardiology,Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014030,China)
Abstract:
Objective To discuss the clinical effect of dabigatran etexilate combined with ticagrelor in the treatment of elderly patients with atrial fibrillation and unstable angina pectoris and its influence on coagulation function.Methods A total of 120 elderly patients with atrial fibrillation and unstable angina pectoris were divided into observation group and control group according to admission order,with 60 cases in each group.The control group was treated with warfarin and ticagrelor on the basis of conventional treatment,while the observation group was treated with dabigatran etexilate combined with ticagrelor on the basis of conventional treatment.The coagulation indexes[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)]before and after treatment,bleeding and occurrence of adverse cardiovascular events were compared between the two groups.Results After 3 and 12 months of treatment,the PT,TT and APTT of the two groups were longer than those before treatment.The PT,TT and APTT after 3 months of treatment of the observation group were(12.65±0.76),(14.24±3.11)and(32.25±4.55)s,which were longer than(11.56±1.85),(12.66±3.15)and(30.42±4.12)s of the control group,and the PT,TT and APTT after 12 months of treatment of the observation group were(13.62±1.32),(16.65±5.12)and(33.76±5.12)s,which were longer than(12.55±2.02),(14.23±7.26)and(31.12±5.87)s of the control group.The difference was statistically significant(P<0.05).The total bleeding rate 3.33%of the observation group was lower than 18.33%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse cardiovascular events between the two groups(χ2=0,P>0.05).Conclusion Dabigatran etexilate combined with ticagrelor shows ideal effect in the treatment of elderly patients with atrial fibrillation and unstable angina pectoris,which can prevent thrombosis and reduce bleeding events with high safety.
Keywords:Atrial fibrillation  Unstable angina pectoris  Dabigatran etexilate  Ticagrelor  Therapeutic effect
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