低剂量多西他赛周疗同步放疗治疗局部晚期食管癌的疗效与安全性分析

目的:探讨单纯放疗与联合低剂量多西他赛周疗同步治疗局部晚期食管癌的近期疗效与风险比较.方法:研究对象是选自2015年01月至2018年08月收治的非手术治疗的64例食管癌患者,随机分为两组:实验组(低剂量多西他赛周疗同步放疗,32例)及对照组(单纯放疗,32例),比较两组患者的近期疗效及不良反应.结果:实验组的治疗有效...

Efficacy and safety of low-dose docetaxel weekly synchronous radiotherapy in the treatment of locally advanced esophageal cancer

Objective:To investigate the short-term efficacy and risk of radiotherapy alone combined with low-dose docetaxel in the treatment of locally advanced esophageal cancer.Methods:Sixty-four patients with esophageal cancer who were treated with non-surgical therapy from January 2015 to August 2018 were randomly divided into two groups:The experimental group(32 patients with low-dose docetaxel weekly concurrent radiotherapy) and the control group(32 patients with radiotherapy alone).Short-term efficacy and adverse reactions of the two groups were compared.Results:The effective rate of treatment in the experimental group was 81.25%,and that in the control group was 56.25%,which was significantly higher in the experimental group than in the control group(P<0.05).The incidence of myelosuppression(leukocytosis and thrombocytopenia) in the experimental group was 68.75% and 43.75%,respectively,significantly higher than that in the control group(37.50%,15.63%),with statistically significant differences(P<0.05).The incidence of gastrointestinal reaction(56.25% vs 31.25%),radioactive esophagitis(31.25% vs 21.88%),and eating obstruction(12.50% vs 9.38%) in the experimental group and the control group were not statistically significant(P>0.05).Conclusion:Low-dose docetaxel weekly synchronous radiotherapy is better than radiotherapy alone in the treatment of locally advanced esophageal cancer,which can alleviate the disease,control tumor progression and improve symptoms,and is safe and effective,worthy of clinical promotion.