| 氧化应激对大鼠糖代谢影响的实验研究 |
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| 引用本文： | 王健,耿跃春,刘少辉,庄明,吴秀娟.氧化应激对大鼠糖代谢影响的实验研究[J].实用全科医学,2010,8(6):673-673,678. |
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| 作者姓名： | 王健 耿跃春 刘少辉 庄明 吴秀娟 |
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| 作者单位： | 王健,耿跃春,刘少辉(江苏省徐州医学科学研究所临床部,221006);庄明,吴秀娟(徐州医学院公共卫生学院) |
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| 基金项目： | 江苏省徐州市社会发展基金资助项目 |
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| 摘 要： | 目的通过观察抗氧化物质VitC、VitE和SOD对糖尿病大鼠体内抗氧化酶和丙二醛的改变，进一步探讨抗氧化活性变化对糖尿病大鼠糖代谢的影响。方法用腹部皮下注射四氧嘧啶的方法对SD大鼠进行糖尿病造模，观察抗氧化物质对糖尿病大鼠血清SOD、GSH—Px、CAT、MDA的影响，进一步了解糖尿病的指标血糖、胰岛素、c肽的改变。结果抗氧化物质具有升高糖尿病大鼠SOD、GSH—Px、CAT活性（P〈0．05），降低MDA含量（P〈0．05）的作用，从而改善了血糖、胰岛素、c肽等糖代谢指标。结论抗氧化物质具有提高机体抗氧化能力和改善糖代谢的作用。
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| 关 键 词： | 糖尿病 抗氧化 超氧化物歧化酶 丙二醛 糖代谢指标 |
The study of Oxidative Stress on Glucose Metabolism in Rats with Experimental |
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| Institution: | WANG Jian, GENG Yao-chun,LIU Shao- hui, et al( Xuzhou Institute of Medical Sciences, Xuzhou 221006, Jiangsu, China) |
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| Abstract: | Objective To further investigate the influence of anti-oxidant activity on glucose metabolism in diabetic rats by observing the effect of antioxidants VitC, VitE and SOD on anti-oxidase and Malondialdehyde of rats in vivo. Methods Diabetes model（ SD rats） were injected alloxan through abdominal subcutaneous,the antioxidants impact on SOD,GSH-Px,CAT and MDA diabetic in rats serum were observed and the change of diabetic indicators including glucose, insulin and C Peptide were recorded. Results Antioxidants had raised the activity of SOD, GSH-Px, CAT and reduced the content of MDA in diabetic rats,thereby improving glycometabolism indicators such as the blood glucose,insulin, C-peptide. Conclusion Antioxidants can improve the antioxidant capacity and improve glucose metabolism. |
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| Keywords: | Diabetes Antioxidase Superoxide dismutase Malondialdehyde Indicators of glycometabolism |
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