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Immunohistochemical analysis of IL-1 Receptor 1 in the discs of patients with temporomandibular joint dysfunction |
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| Authors: | Luis Eduardo Almeida Adam Sorenson Kyle Hresko Seth Butcher Rosalia Leonardi Carla Loreto |
| Institution: | 1. Surgical Sciences Department, Oral and Maxillofacial Surgery, School of Dentistry, Marquette University, Milwaukee, WI, USA;2. Department of Orthodontics and Orofacial Pain, University of Catania, Catania, Italy;3. Department of Bio-Medical Sciences, Anatomy Section, University of Catania, Catania, Italy |
| Abstract: | Objective Temporomandibular joint dysfunction (TMD) may affect a patient’s quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD. Methods Thirty-nine human disc samples were collected and composed three different groups: ADDwR (n = 19), ADDwoR (n = 12), and control group (n = 8). The samples were immunostained with IL-1R1 antibody and evaluated on both quantity and intensity of staining. Results There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining. Conclusion IL1-R1 was associated with ADDwR and ADDwoR in TMD discs of humans. |
| Keywords: | TMJ interleukin 1 inflammation |