药源性间质性肺疾病

药源性间质性肺疾病(DI-ILD)是最常见的药源性肺部疾病,目前已知多种药物可导致间质性肺疾病,其发病机制与药物引起的变态反应和直接细胞毒性作用有关。此类疾病临床症状、影像学及组织病理学表现均无特异性,临床诊断DI-ILD需根据病史(用药史)、临床特点、胸部影像学、组织病理学改变及治疗效果。临床疑诊DI-ILD时应立刻停药并应用糖皮质激素。若及时干预,预后良好。

Drug-induced interstitial lung diseases

Drug-induced interstitial lung disease is the most common type of drug-induced respiratory diseases.It is known that a lot of drugs can cause interstitial lung diseases.The underlying mechanism may be associated with allergy and the direct cellular toxicity.Its clinical symptoms,imaging,and histopathology were untypical.Clinical diagnosis of the disease was based on the medical history（medication history）,clinical features,chest imaging,histopathological changes,and response to treatment.If interstitial lung diseases were suspected to be drug-induced,the drug should be discontinued immediately and glucocorticoid could be given.The prognosis is good if intervention is rapid.