| 滥服盐酸二甲双胍减肥致肝损害 |
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| 引用本文： | 任爱民,李红,沈淑凤,梁东竹.滥服盐酸二甲双胍减肥致肝损害[J].药物不良反应杂志,2012,14(3):167-168. |
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| 作者姓名： | 任爱民 李红 沈淑凤 梁东竹 |
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| 作者单位： | 首都医科大学附属北京地坛医院综合一科,100015 |
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| 摘 要： | 1例29岁女性为减肥自行服用盐酸二甲双胍500 mg,3次/d。约1年后出现发热伴上腹部不适、呕吐、尿黄、陶土样大便。肝功能检查：丙氨酸转氨酶（ALT）782 U/L,天冬氨酸转氨酶（AST）346 U/L,总胆红素26μmol/L,C反应蛋白23 mg/L。停用盐酸二甲双胍,给予保肝治疗。15 d后复查肝功能：ALT 65 U/L,AST 50 U/L。
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| 关 键 词： | 二甲双胍 肝炎 药物性 |
Liver damage after abuse of metformin hydrochloride to lose weight |
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| REN Ai-min
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LI Hong
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SHEN Shu-feng
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LIANG Dong-zhu.Liver damage after abuse of metformin hydrochloride to lose weight[J].Adverse Drug Reactions Journal,2012,14(3):167-168. |
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| Authors: | REN Ai-min LI Hong SHEN Shu-feng LIANG Dong-zhu |
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| Institution: | . Department of Synthetic No.1, Beijing Ditan Hospital, Capital Medical Uni- versity, Belting 100015, China |
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| Abstract: | A 29-year-old female self-administered metformin hydrochloride 500 mg thrice daily to lose weight. About one year later, she developed fever, upper abdominal pain, vomiting, yellowish urine, and clay-like stool. The liver function tests revealed the following levels ： alanine aminotransferase （ALT） 782 U/L, aspartate aminotransferase （AST） 346 U/L, total bilirubin 26 p, mol/L, C- reactive protein 23 mg/L. Mefformin hydroehloride was withdrawn and liver-protective treatment was given. Fifteen days later, repeat liver function tests showed an ALT level of 65 U/L and an AST level of 50 U/L. |
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| Keywords: | metformin hepatitis drug-induced |
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