Bioavailability of two hydrochlorothiazide preparations |
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| Authors: | B. Beermann M. Groschinsky-Grind B. Lindström |
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| Affiliation: | (1) Department of Medicine and Clinical Pharmacology Laboratory, Serafimerlasarettet, Sweden;(2) Division of Clinical Drug Trials, Department of Drugs, National Board of Health and Welfare, Uppsala, Sweden |
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| Abstract: | Summary Eight healthy volunteers received hydrochlorothiazide 75 mg as Dichlotride and Esidrex. Maximal plasma levels were significantly (p<0.05) higher after Dichlotride than Esidrex, 512±189 and 376±70 ng/ml, respectively. However, the bioavailability of the two brands of hydrochlorothiazide did not differ significantly as judged by comparison of the AUC0 9h and AUC0 , and the urinary recovery of hydrochlorothiazide during 48 hrs.Supported by the Swedish Medical Research Council (Grant No. B 75-04X-227-12 C) and Hässle-Ciba-Geigy AB, Gothenburg, Sweden |
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| Keywords: | Bioavailability diuretics gastrointestinal absorption hydrochlorothiazide thiazides |
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