Preliminary findings in the evaluation of hepatic malignancies by radioimmunodetection,X-ray computed tomography,and magnetic resonance imaging |
| |
| Authors: | Frank H DeLand Arthur Lieber Madhira D Ram David M Goldenberg |
| |
| Institution: | (1) Department of Radiation Medicine (Division of Nuclear Medicine), University of Kentucky, Lexington, KY;(2) Department of Radiology, University of Kentucky, Lexington, KY;(3) Department of Surgery, University of Kentucky, Lexington, KY;(4) Veterans Administration Medical Centers, Lexington, KY;(5) the Center for Molecular Medicine and Immunology at the University of Medicine and Dentistry of New Jersey, Newark, NJ;(6) Veterans Administration Medical Center, 800 Irving Avenue, 13210 Syracuse, NY, USA |
| |
| Abstract: | In 12 consecutive patients with suspected metastatic carcinoma of the liver, we evaluated the sensitivity of radiolabeled antibodies to tumor antigens, magnetic resonance imaging, and X-ray computed tomography imaging in the detection of hepatic malignancies. Studies were performed with 131I labeled antibodies to CEA and/or CSAp; polyclonal, monoclonal and F(ab )2 antibodies were used. Nontarget radioactivity was diminished by administration of 99mTc reagents simulating nontumor distribution and use of a computer substraction method. In nine patients with confirmed liver neoplasms, radioimunodetection disclosed the foci of hepatic malignancies. In three patients with suspected liver neoplasms, the antibody studies were positive, but at this time have not been confirmed. X-ray computed tomography each disclosed mass lesions in five patients and magnetic resonance in three. These findings suggest that radioimmunodetection provides greater accuracy in the detection and localization of cancer than other diagnostic modalities currently used.This research was supported in part by NIH Grants CA37408, CA37409, CA37412, and CA39841 |
| |
| Keywords: | Radioimmunodetection Tumor detection Antibodies |
| 本文献已被 SpringerLink 等数据库收录！ |
|
