Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice |
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| Authors: | Nakasone Chikara Kawakami Kazuyoshi Hoshino Tomoaki Kawase Yusuke Yokota Koichi Yoshino Kohichiro Takeda Kiyoshi Akira Shizuo Saito Atsushi |
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| Affiliation: | Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. |
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| Abstract: | We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa. |
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