The role of Na+‐K+‐ATPase in the epileptic brain |
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| Authors: | Jinyi Sun Yang Zheng Zhong Chen Yi Wang |
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| Affiliation: | 1. Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou China ; 2. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou China ; 3. Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou China |
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| Abstract: | ![]()
Na+‐K+‐ATPase, a P‐type ATP‐powered ion transporter on cell membrane, plays a vital role in cellular excitability. Cellular hyperexcitability, accompanied by hypersynchronous firing, is an important basis for seizures/epilepsy. An increasing number of studies point to a significant contribution of Na+‐K+‐ATPase to epilepsy, although discordant results exist. In this review, we comprehensively summarize the structure and physiological function of Na+‐K+‐ATPase in the central nervous system and critically evaluate the role of Na+‐K+‐ATPase in the epileptic brain. Importantly, we further provide perspectives on some possible research directions and discuss its potential as a therapeutic target for the treatment of epilepsy. |
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| Keywords: | drug target, epilepsy, excitability, Na+‐ K+‐ ATPase |
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