雷替曲塞的临床应用

目的总结分析雷替曲塞，临床应用现状，寻求雷替曲塞合理用药的方法。方法通过搜索国内外有关雷替曲塞临床应用的文献资料，分析总结已公开发表的雷替曲塞临床数据。结果雷替曲塞（3mg·m^-2）治疗结直肠癌和恶性胸膜间皮瘤疗效较佳，单药雷替曲塞一线治疗疗效是二线治疗的两倍。老年人和儿童应用雷替曲塞治疗时需减量，雷替曲塞不良反应相对较少，但治疗中出现的一过性转氨酶升高需要注意。结论通过患者的病种、病情和体质等选择雷替曲塞用量与用法能够实现合理用药。

Clinical Use of Raltitrexed

OBJECTIVE To analysis the clinical application situation ofraltitrexed and seek for the method for the rational use of raltitrexed. METHODS Through search the clinical document literature of raltitrexed to summarize the published clinical data. RESULTS Raltitrexed （3 mg·m^-2） has good effect on colorectal cancer and malignant pleural mesotheliomaand. Single-agent of raltitrexed first-line treatment efficacy is twice the second-line therapy. The olds and children need reduce the dosage. Although the adverse drug reactions of raltitrexed are relatively less, the transient transaminase lifts need to be paid more attention. CONCLUSION It makes sense to select rational dosage and usage based on patient, disease condition and patient＇s physical quality in order to achieve the best clinical efficacy.