首页 | 本学科首页   官方微博 | 高级检索  
     


Evolution of MHC-G in humans and primates based on three new 3'UT polymorphisms
Authors:Castro M J  Morales P  Martínez-Laso J  Allende L  Rojo-Amigo R  González-Hevilla M  Varela P  Moreno A  García-Berciano M  Arnaiz-Villena A
Affiliation:Department of Immunology and Molecular Biology, Hospital "12 de Octubre," Universidad Complutense, Madrid, Spain.
Abstract:MHC-G is a class Ib (non-classical) major histocompatibility complex (MHC) whose functional and evolutionary characteristics are still under scrutiny. The study of noncoding sequences in the MHC genes may provide important phylogenetic information. In this work we have sequenced the MHC-G exon 8, which encodes for the 3'UT region, in different species of primates. It has been shown that: (1) a previously described 14 base pair (bp) deletion polymorphism is human-specific and the HLA-G alleles may be classified according to its absence or presence; (2) another newly described 3 bp deletion/insertion polymorphism is also human-specific; and (3) another newly described 51 bp deletion polymorphism is common to Pongidae and humans, but is not found in other primates belonging to the Cercopithecinae family. A hypothesis on the evolutionary pathway of this gene is put forward in the light of these findings.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号