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甘露醇对早期脑出血患者治疗后颅内血肿变化的影响
引用本文:苗海锋,肖卫民,江东新. 甘露醇对早期脑出血患者治疗后颅内血肿变化的影响[J]. 中国实用神经疾病杂志, 2009, 12(7)
作者姓名:苗海锋  肖卫民  江东新
作者单位:广东东莞市人民医院神经内科,东莞,523018;广东东莞市人民医院神经内科,东莞,523018;广东东莞市人民医院神经内科,东莞,523018
摘    要:目的 观察早期高血压性脑出血患者甘露醇治疗前后颅内血肿的大小,经颅多普勒血流动力学参数,以及血浆内皮素-1水平的变化,对如何正确使用甘露醇作初步探讨.方法 160例高血压性脑出血患者随机分为甘露醇治疗组和非甘露醇治疗组,头颅CT测定血肿大小、TCD测定大脑中动脉平均血流速度(blood flow mean velocity, Vm)及脉动指数(pulse index, PI),使用放免法测定血浆内皮素-1水平,对实验前后上述参数的变化进行统计学分析.结果 治疗前2组患者血肿大小、Vm和PI值以及血浆内皮素-1水平比较,P>0.05,差异无统计学意义;而治疗后甘露醇治疗组血肿大小、Vm值及PI值分别较该组患者治疗前增加、减小、增加;非甘露醇治疗组上述值则分别较治疗前减小、增加、减小,治疗前后比较,P均<0.05,差异有统计学意义.结论 血浆内皮素-1水平对判断高血压性脑出血患者的预后有一定的参考意义,早期发病的少量高血压脑出血患者慎用甘露醇脱水治疗,以免血肿扩大,TCD血流动力学参数对脱水治疗有指导意义.

关 键 词:经颅多普勒  甘露醇  血浆内皮素-1  脑出血

Changes of hematoma in initial stage cerebral hemorrhage patients treated with mannitol
Miao Haifeng,Xiao Weimin,Jiang Dongxin. Changes of hematoma in initial stage cerebral hemorrhage patients treated with mannitol[J]. Chinese Journal of Practical Neruous Diseases, 2009, 12(7)
Authors:Miao Haifeng  Xiao Weimin  Jiang Dongxin
Affiliation:Miao Haifeng,Xiao Weimin,Jiang Dongxin.Department of Neurology,Dongguan City People's Hospital,Dongguan 523018,China
Abstract:Objective To investigate the changes of hematoma sizes,TCD hemodynamics parametes,plasma endothelin-1 in prior treatment and post-treatment patients,and to discuss initially how to use mannitol correctly.Methods One hundred and sixty cerebral hemorrhage patients caused by hypertension were grouped randomly mannitol-treated group and non-mannitol-treated group. Hematoma size,Vms and PIs of medium-sized artery were measured by head-CT and TCD respectively,and plasma endothelin-1 was evaluated with radioimmuni...
Keywords:Transcranial Doppler  Mannitol  Plasma endothelin-1  Cerebral hemorrhage  
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