|
|||||
|
|
| 淋巴细胞表面CCR5在HCV与HIV感染中表达 | |
| 引用本文： | 康辉,王亚男,范霞,刁莹莹,代娣,尚红. 淋巴细胞表面CCR5在HCV与HIV感染中表达[J]. 中国公共卫生, 2006, 22(4): 421-422 |
| 作者姓名： | 康辉 王亚男 范霞 刁莹莹 代娣 尚红 |
| 作者单位： | 中国医科大学第一临床医院,沈阳,110001 |
| 基金项目： | 科技部专项基金;辽宁省教育厅资助项目 |
| 摘 要： | 目的探讨T淋巴细胞表面C—C趋化因子受体5（CCR5）在丙型肝炎病毒（HCV）感染、人类免疫缺陷病毒（HIV）感染和HCV／HIV合并感染过程中的表达及意义。方法采用流式细胞术检测HCV感染组（n=21例），HIV感染组（n=14例），HCV／HIV感染组（n=28例）及正常对照组（n=30例）人外周血CD4＋和CD8＋T淋巴细胞表面CCR5的表达。结果与正常对照组相比，外周血CD4^＋和CD8^＋T淋巴细胞表面CCR5，HIV感染组高表达（P〈0．01），HCV感染组和HCV／HIV合并感染组中低表达（P〈0．01）。结论淋巴细胞表面CCR5的表达，HIV感染时升高、HCV感染时降低，HCV／HIV合并感染时HCV感染的作用更强。 |
| 关 键 词： | C-C趋化因子受体5(CCR5) 丙型肝炎病毒(HCV) 人类免疫缺陷病毒(HIV) HCV/HIV合并感染 |
| 文章编号： | 1001-0580(2006)04-0421-02 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-09-12 |
Expression of lymphocyte surface CCR5 in HCV and HIV infection |
|
| KANG Hui , WANG Yanan, FAN Xia, et al. Expression of lymphocyte surface CCR5 in HCV and HIV infection[J]. Chinese Journal of Public Health, 2006, 22(4): 421-422 | |
| Authors: | KANG Hui WANG Yanan FAN Xia et al |
| Affiliation: | Department of Medical Laboratory, The First Affiliated Hospital of China Medicial University, Shenyang 110001, China |
| Abstract: | Objective To investigate expression and significance of CC-chemokine receptor 5(CCR5) in HCV mono-infection,HIV mono-infection and HCV/HIV co-infection.Methods The surface expression of CCR5 on CD4~+T cells and CD8~+T cells from PBMC isolated from HCV infection(n=21),HIV infection(n=14),HCV/HIV co-infection(n=28) and normal control(n=30) by flow cytometry.Results The expression of CCR5 on CD4~+ and CD8~+ T lymphocytes increased significantly in HIV mono-infection(P<0.01),but decreased significantly both in HCV mono-infection and HCV/HIV co-infection(P<0.01).Conclusion The surface expression of CCR5 on lymphocytes increased with HIV infection,decreased with HCV infection.In HCV/HIV co-infection,HCV maybe effect on the expression of CCR5 on lymphocytes. |
| Keywords: | CC-chemokine receptor 5(CCR5) HCV HIV HCV/HIV co-infection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |