白细胞介素6基因174G/C多态性与胰岛素抵抗的关系

目的了解中国南方汉族人白细胞介素6基因174G/C多态性与胰岛素抵抗的关系.方法应用聚合酶链反应一限制片长多态性分析方法测定了69例胰岛素抵抗指数高值者和69例胰岛素抵抗指数低值者的白细胞介素6基因174G/C多态性,并结合血压、血糖、血脂等相关指标进行横断面分析.结果中国南方汉族人白细胞介素6基因174G/C多态性以GG纯合子基因型为主,分布频率为136/138(98.55%),GC杂合子基因型分布频率为2/138(1.45%),CC突变基因型未发现,各基因型与胰岛素抵抗指数无相关性.结论中国南方汉族人白细胞介素6基因174G/C多态性与胰岛素抵抗可能无关.

The Relationship of Interleukin-6 Gene 174G/C Polymorphism and Insulin Resistance

Aim To understand the relationship of interleukin-6-gene 174G/C polymorphism and insulin resistance in Han people in south China. Methods Interleukin-6-gene 174G/C polymorphism were detected in 69 patients with high insulin resistance index and 69 control with low insulin resistance index by polymerase chain reaction-restriction fragment length polymorphism analytical method, meanwhile, combined with blood pressure, plasma glucose, blood fat, et al to undertake cross-sectional study. Results In Han people in south China, interleukin-6-gene 174G/C polymorphism main was G/G homogenotype and distribution frequency was 136/138 (98.55%), G/C hetrogenotype distribution frequency was 2/138(1.45%), C/C mutant genotype had not been found. There was no relationship between the kinds of genotype and insulin resistance index. Conclusion Maybe there is no relationship between interleukin-6-gene 174G/C polymorphism and insulin resistance in Han people in south China.