脊髓灰质炎疫苗免疫的研究 I.免疫程序的改进观察

本文报告了对脊髓灰质炎疫苗现行免疫程序的改进观察血清学结果。对已服完3次疫苗的18~24月龄儿童加服一次疫苗,可获得良好的免疫应答。血清中和抗体阳转率Ⅰ型由85%提高到96%,Ⅱ型由84%提高到100%,Ⅲ型由91%提高到100%,3个型的抗体GMT都有大幅度增长。18~24月龄加服一次疫苗对消除服完3次疫苗儿童发病将起到十分重要作用。在当前全国消灭脊髓灰质炎工作中推荐各地对已服完3次疫苗18~24月龄的儿童集中普服。新生儿出生后服苗,80%可从肠道排毒,对日后3次常规服苗阳转率似有提高作用。

A Study on Immunization of Polio Vaccinel. Observation on An Improved Immunization Schedule

This artical reports the result of serological observation on an improved immunization schedule of polio vaccine. The result shows that a good response can be obtained by immunizing an additional dose of the vaccine on the children of 18-24 month of age.serological convertion type I of neutralization antibody can be improved from 85% up to 96%, type II from 84% to 100%, and type III from 91% to 100%, with great increase of all the three types. The study proves that the additional immunization of the vaccine will effectively control over the incidence occurrence of the children who have received three doses of the vaccine within 3 years of age. An nation-wide extensive inoculation of the vaccine among the children who have received three doses of the vaccine is suggested. 81% of neonates inoculated with the vaccine within 24 hours after birth can discharge the polio-vaccine-virus through their intestinal canal and the inoculation has some effect on the improvement of the seroconversion obtained from the immunization of the three doses of the vaccine afterwards.