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Immunological Response of Guinea Pigs Sensitized With Homologous Antigens |
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| Authors: | ANGEL ALONSO Dr. JOSEFINA M.S. DE CEREZO NÉLIDA GONZALEZ MARÍA P. BUENO ROBERTO S. MANCINI |
| Affiliation: | 1. Centra de Alergia e Immunologia, Hospital de Clinicas Jose de San Martin, and Centro de Inuestigaeiones en Reproductión, Facultad de Medicina, Buenos Aires;2. Centra de Alergia e Immunologia, Hospital de Clinicas Jose de San Martin, and Centro de Inuestigaeiones en Reproductión, Facultad de Medicina, Buenos Aires Dr. R. Mancini passed away February 1977. |
| Abstract: | ABSTRACT: The chemical composition of some “immunologically” pure antigens isolated from guinea pig testis and spermatozoa was correlated with their antigenic behavior. Their immunological responses were compared to select the best materials for a further isolation of chemically pure antigens. The glycoprotein extracted from the spermatozoa (T Gly) has the highest immunological potency and seems to be a T and B, depending antigen, able to induce high humoral and cell responses producing germinal cell damage, testicular lesions, and aspermatogenesis. |
| Keywords: | Glycoprotein spermatozoa guinea pig antigens testis |