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Red-Cell Sensitization in Myelofibrosis
Authors:Hans Hasselbalch  Dag Berild  Ole Paaske Hansen
Affiliation:University Department of Medicine and Haematology, Gentofte Hospital, Copenhagen, Denmark
Abstract:
Using an enzyme-linked immunosorbent assay (ELISA), elevated RBC-Ig of the IgG and IgM class were found in 8 of 14 patients with idiopathic myelofibrosis. In 2 patients with high levels of RBC-Ig the direct Coombs' test was positive. It is supposed that immune haemolysis may contribute to the anaemia in some patients with idiopathic myelofibrosis.
Keywords:membrane bound Ig  myelofibrosis  red cell sensitization
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