| 辛芷离子敏感型鼻用原位凝胶的研制及体外释药评价 |
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| 引用本文： | 卓玉娟,刘新,喻录容,张桂平. 辛芷离子敏感型鼻用原位凝胶的研制及体外释药评价[J]. 中国医院药学杂志, 2010, 0(1) |
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| 作者姓名： | 卓玉娟 刘新 喻录容 张桂平 |
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| 作者单位： | 重庆医科大学药学院;重庆医科大学中医药学院; |
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| 摘 要： | 目的:开发一种新型的中药鼻腔给药系统剂型—原位凝胶。方法:采用去乙酰结冷胶为材料制备辛芷离子敏感型鼻用原位凝胶。研究不同浓度去酰基结冷胶原位凝胶的黏度特性,采用扩散池法考察其体外释药规律,并用无膜溶出法研究其释药机制。结果:辛芷离子敏感型鼻用原位凝胶的黏度随去酰基结冷胶的浓度增加而增大,其释药量随结冷胶的浓度增加而减少,其释药符合一级释药模型,其溶蚀度较小且与释放率无明显相关性(r=0.986)。结论:应用去酰基结冷胶可成功制备离子敏感型中药鼻用原位凝胶,为中药鼻腔给药提供了一种新剂型。
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| 关 键 词： | 去酰基结冷胶 离子敏感型 原位凝胶 体外释药 |
Preparation of Xinzhi ion-activated nasal in situ gel and evaluation of drug release in vitro |
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| ZHUO Yu-juan,LIU Xin,YU Lu-rong,ZHANG Gui-ping. Preparation of Xinzhi ion-activated nasal in situ gel and evaluation of drug release in vitro[J]. Chinese Journal of Hospital Pharmacy, 2010, 0(1) |
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| Authors: | ZHUO Yu-juan LIU Xin YU Lu-rong ZHANG Gui-ping |
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| Affiliation: | ZHUO Yu-juan1,LIU Xin1,YU Lu-rong2,ZHANG Gui-ping1(1.Pharmacy Departement,2.Chinese Medicine Departement,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | OBJECTIVE To develop a novel,in situ gel system for nasal delivery of China traditional medicine.METHODS A series of Xinzhi ion-activated Nasal in situ gel was preparated employing gellan gum as material.Characteristic of their viscosity was studied.Regularity of the drug release was studied by using the diffusion cell model and mechanism of the drug release was study by using the membrane-less dissolution model.RESULTS The viscosity of the gellan gum formulations either in solution or in gel increased with... |
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| Keywords: | deacetylatd gellan gum nasal ion-activated in situ gel drug release in vitro |
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