IgA肾病患者血清瘦素水平变化及其临床意义

目的:探讨IgA肾病患者血清中瘦素(leptin)水平变化的特点及其临床意义。方法:选取40例IgA肾病患者,按照是否需要透析治疗标准划分为A组(无需透析治疗)、B组(需长期透析治疗)及C组(健康体检者),每组各20例(n=20)。收集晨起空腹血清(B组外加透析前后的血清),采用竞争性放射免疫分析法(RIA)检测leptin的水平并分析其临床意义。结果:A、B、C组血清leptin的平均水平分别为(4.98±0.78)μg/L、(6.45±0.76)μg/L及(3.96±0.56)μg/L。A、B组血清leptin的平均水平显著高于正常对照C组(P<0.05);B组血清Leptin的平均水平明显高于A组(P<0.05);B组患者透析前后血清leptin的平均水平分别为(6.50±0.86)μg/L及(5.21±0.66)μg/L,透析后血清leptin的平均水平显著低于透析前(P<0.05)。结论:IgA肾病患者存在血清leptin的水平明显升高,血液透析能降低其血清水平,提示leptin可能在IgA肾病发生发展中起着重要的作用。

The clinical significance of serum leptin level in IgA nephropathy patients

AIM: To explore the change of serum leptin level and its clinical significance in the patients with IgA nephropathy.METHODS: A total of 40 IgA nephropathy patients were divided into group A(unnecessary for hemodialysis regimen) and B group(requisite for hemodialysis regimen).Other 20 healthy people for health examination homeochronously in our hospital were used as the control group(C group).The radioimmunoassay(RIA) was performed to detect the serum leptin contents of all the individuals and to analyze its clinical significance.RESULTS: The mean serum concentrations(MSCs) of A,B and C group were(4.98±0.78) μg/L,(6.45±0.76) μg/L and(3.96±0.56) μg/L,respectively.And the MSCs before and after dialysis of group B patients were(6.50±0.86) μg/L and(5.21±0.66) μg/L,respectively.Statistical analysis indicated that the MSCs of group A and B were significantly higher than that of group C,and group B was obviously higher than that of group A(P<0.05).The MSC before dialysis was statistically higher than that after dialysis in group B(P<0.05).CONCLUSION: The serum leptin was significantly increased in IgA nephropathy patients,which may be significant in the progression of IgA nephropathy.