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| p16蛋白在肾母细胞瘤中的表达 | |
| 引用本文： | 宋兰云,王学文,胡晓丽,宁培儒. p16蛋白在肾母细胞瘤中的表达[J]. 天津医药, 2003, 31(1): 23-24 |
| 作者姓名： | 宋兰云 王学文 胡晓丽 宁培儒 |
| 作者单位： | 300074,天津市儿童医院病理科 |
| 摘 要： | 目的:探讨p16蛋白在肾母细胞瘤中的表达及临床意义。方法:应用S-P免疫组织化学方法对42例肾母细胞瘤常规石蜡标本进行p16蛋白检测。结果:42例中p16蛋白表达缺失率为69.05％,p16蛋白阳性表达与病理组织类型、患儿预后显著相关(P<0.01),阳性表达者预后好。结论:p16蛋白表达可作为判断肾母细胞瘤预后的指标。 |
| 关 键 词： | 肾母细胞瘤 蛋白质p16 免疫组织化学 基因表达 |
Significance of p16 Protein Expression in Nephroblastoma |
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| SONG Lanyun.WANG Xuewen.HU Xiaoli,NING Peiru. Significance of p16 Protein Expression in Nephroblastoma[J]. Tianjin Medical Journal, 2003, 31(1): 23-24 | |
| Authors: | SONG Lanyun.WANG Xuewen.HU Xiaoli NING Peiru |
| Affiliation: | SONG Lanyun.WANG Xuewen.HU Xiaoli,NING Peiru Department of Pathology,Tianjin Children' s Hospital,Tianjin 300074,China |
| Abstract: | Objective: To study the significance of p16 protein expression in nephroblastoma. Methods: The p16 expression was studied with immunohistochemical method in 42 patients with nephroblastoma.Results:The negative rate of p16 protein expression was 69.05%.The positive rate of p16 protein expression was significantly related to pathological types and prognosis(P<0. 01). The prognosis was better in positive case than that in negative case.Conclusion: The p16 protein expression can be used as a marker to predict the prognosis of nephroblastoma. |
| Keywords: | nephroblastoma protein p16 immunohistochemistry gene expression |
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