| 姜黄素对糖尿病脑病大鼠海马IGF-1/IGF-1R表达的影响 |
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| 引用本文： | 胡义平,魏倩萍,陈艳瑜. 姜黄素对糖尿病脑病大鼠海马IGF-1/IGF-1R表达的影响[J]. 免疫学杂志, 2011, 0(3): 203-206 |
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| 作者姓名： | 胡义平 魏倩萍 陈艳瑜 |
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| 作者单位： | 重庆医科大学附属第一医院老年科; |
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| 摘 要： | 目的观察姜黄素对糖尿病脑病大鼠胰岛素样生长因子1(IGF-1)、胰岛素样生长因子受体(IGF-1R)表达的影响,分析姜黄素的脑保护作用机制。方法实验动物分为4组:正常对照组(A组)、正常姜黄素组(B组)、糖尿病脑病组(C组)和姜黄素治疗组(D组)。以大鼠一次性腹腔注射链脲佐菌素(STZ)建立糖尿病脑病模型,姜黄素持续灌胃12周。观察大鼠的体质量、血糖、糖化血红蛋白变化,采用免疫组化、RT-PCR法检测IGF-1及IGF-1R表达的变化。结果与A组和B组大鼠相比,C组大鼠血糖、糖化血红蛋白明显增高,体质量下降,海马区IGF-1表达明显减少(P<0.05),同样海马神经元IGF-1R表达减少(P<0.05)。经姜黄素治疗后,D组大鼠糖化血红蛋白下降,体质量增加,血糖变化不大,海马神经元IGF-1表达增多(P<0.05),随之海马神经元IGF-1R表达增多(P<0.05)。结论大鼠海马IGF-1/IGF-1R表达的减少可能在糖尿病脑病发病机制中发挥着重要的作用,姜黄素有脑保护作用,其机制可能是通过调控IGF-1信号通路调节实现的。
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| 关 键 词： | 糖尿病脑病 胰岛素样生长因子-1 胰岛素样生长因子1受体 姜黄素 |
Impact of curcumin on the expression of IGF-1/IGF-1R in hippocampal neuron of diabetic encephalopathy rats |
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| HU Yiping,WEI Qianping,CHEN Yanyu. Impact of curcumin on the expression of IGF-1/IGF-1R in hippocampal neuron of diabetic encephalopathy rats[J]. Immunological Journal, 2011, 0(3): 203-206 |
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| Authors: | HU Yiping WEI Qianping CHEN Yanyu |
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| Affiliation: | HU Yiping,WEI Qianping,CHEN Yanyu Department of Gerontology,First Affiliated Hospital,Chongqing Medical University,400016 Chongqing,China |
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| Abstract: | We aimed to study the impact of curcumin on IGF-1/IGF-1R tentatively and the protective mechanism against diabetic encephalopathy.Rats were randomly divided into 4 groups: normal controls(group A),curcumin-treated normal controls(group B),untreated models(group C),and curcumin-treated models(group D).Rat received a single dose of Streptozotocin(STZ) to make the experimental model of diabetic encephalopathy,followed by supplementation with curcumin for 12 weeks.The rats were examined for weight,blood glucose... |
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| Keywords: | Diabetic encephalopathy IGF-1 IGF-1R Curcumin |
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