布地奈德联合特布他林对慢性阻塞性肺疾病患者肺功能的影响

目的:探究布地奈德与特布他林联合应用于慢性阻塞性肺疾病(COPD)患者中的治疗效果,并探究其对患者肺功能的影响。方法:选取某院2018年4月~2019年3月收治的COPD患者(n=82例)为实验对象,依据不同的治疗方法,将入选患者分为联合组及单一组,每组41例,其中单一组采用特布他林治疗,联合组采用特布他林联合布地奈德治疗。观察两组患者的治疗效果、不良反应及其治疗前后的肺功能改善情况。结果:联合组的治疗总有效率为95.12%,与单一组的75.61%比较,两者差异显著(χ^2=6.248,P<0.05)。联合组治疗后FEV1为(2.46±0.97)L,显著高于单一组[(1.35±0.32)L,P<0.05];FVC为(2.84±0.66)L,显著高于单一组[(2.26±0.15)L,P<0.05];FEV1/FVC为(65.51±8.96),显著高于单一组[(58.31±7.93),P<0.05]。联合组的总不良反应率为7.32%,低于单一组的12.20%,但差异不显著(χ^2=0.554,P>0.05)。结论:布地奈德结合特布他林治疗COPD具有较好的治疗效果,可显著改善患者的肺功能,减少不良反应,安全性高。

Effect of Budesonide Combined with Terbutaline on Lung Function in Patients with Chronic Obstructive Pulmonary Disease

Objective:To explore the efficacy of budesonide combined with terbutaline in the treatment of patients with chronic obstructive pulmonary disease(COPD) and to explore its effect on lung function. Methods:82 COPD patients admitted to a hospital from April 2018 to March 2019 were selected as experimental subjects. According to different treatment methods, the enrolled patients were divided into a combined group and a single group, with 41 cases in each group. The single group was treated with terbutaline, and the combined group was treated with terbutaline and budesonide. The therapeutic effect, adverse reactions and the improvement of lung function before and after treatment were observed. Results: The total effective rate was 95.12% in the combined group, compared with 75.61% in the single group, the difference was significant(χ^2=6.248, P<0.05). After treatment, FEV1 in the combined group was(2.46±0.97)L, significantly higher than that in the single group [(1.35±0.32)L, P<0.05];FVC was(2.84±0.66)L, significantly higher than that of the single group [(2.26±0.15)L, P<0.05];FEV1/FVC was(65.51±8.96), significantly higher than that of the single group [(58.31±7.93), P<0.05]. The total adverse reaction rate of the combined group was 7.32%, which was 12.20% lower than that of the single group, but the difference was not significant(χ^2=0.554, P>0.05). Conclusion:Budesonide combined with terbutaline in the treatment of COPD has a good therapeutic effect, it can significantly improve patients’ lung function, reduce adverse reactions, with high safety.