| 急性髓系白血病中CD64表达的敏感性及特异性研究 |
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| 引用本文： | 靳海杰,高晓宁,陈卫华,李猛,孙敬芬,韩晓蘋,于力.急性髓系白血病中CD64表达的敏感性及特异性研究[J].标记免疫分析与临床,2008,15(4). |
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| 作者姓名： | 靳海杰 高晓宁 陈卫华 李猛 孙敬芬 韩晓蘋 于力 |
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| 作者单位： | 解放军总医院血液科,北京,100853 |
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| 摘 要： | 研究急性髓系白血病(AML)免疫分型中CD64的敏感性和特异性.用系列抗原对132例AML患者的骨髓细胞进行直接标记,并用流式细胞术进行分析.结果表明:在AML中,CD64对急性粒-单细胞白血病(M4)和急性单核细胞白血病(M5)中敏感性最高(分别为96.4%和100%),在其他AML(M0、M1、M2、M3,M6、M7)中表达均较低.CD64对M4和M5中的特异性为56.5%.因此,CD64有助于AML中M4、M5的鉴别诊断.
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| 关 键 词： | 急性髓系白血病 流式细胞术 |
A Study of Sensitivity and Specificity of CD64 Expression in Acute Myeloid Leukemia |
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| JIN Hai-lie,GAO Xiao-ning,CHEN Wei-hua,LI Meng,SUN Jiang-fan,HAN Xiao-pin,YU Li.A Study of Sensitivity and Specificity of CD64 Expression in Acute Myeloid Leukemia[J].Labeled Immunoassays and Clinical Medicine,2008,15(4). |
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| Authors: | JIN Hai-lie GAO Xiao-ning CHEN Wei-hua LI Meng SUN Jiang-fan HAN Xiao-pin YU Li |
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| Abstract: | To study the sensitivity and specificity of CD64 in immunotyping of acute myeloid leukemia(AML).The bone marrow cells from 132 patients with AML were labelled with a series of antigens and were analyzed by flow cytometry.CD64 has high sensitivity in patients with acute myelomonocytic leukemia(M4) 96.4% and acute monocytic leukemia(M5)(96.4% and 100%,respectively).The expressions of CD64 was very low on patients with other kinds of AML(M0,M1,M2,M3,M6,M7).The specificity of CD64 in patients with M4 and M5 was 56.5%.The results suggest that the CD64 is helpful in the differential diagnosis of M4 and M5 in AML patients. |
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| Keywords: | CD64 |
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