| 板蓝根脂溶性提取物固体分散体的溶解特性研究 |
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| 引用本文： | 王璐璐,郑稳生.板蓝根脂溶性提取物固体分散体的溶解特性研究[J].中国医药工业杂志,2006,37(1):23-25. |
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| 作者姓名： | 王璐璐 郑稳生 |
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| 作者单位： | 中国医学科学院协和医科大学药物研究所,北京,100050 |
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| 摘 要： | 分别以PVP K30、PEG6000、泊洛沙姆188为载体制备板蓝根脂溶性提取物的固体分散体，并以靛玉红为指标，采用HPLC法测定含量以考察制得固体分散体的溶解特性。结果显示，3种固体分散体均能显著增加板蓝根脂溶性成分在水中的溶解度，但随时间延长，溶解度下降，以PVP K30为载体的制品下降趋势最缓。
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| 关 键 词： | 板蓝根 固体分散体 靛玉红 溶解度 高效液相色谱 |
| 文章编号： | 1001-8255（2006）01-0023-03 |
| 收稿时间： | 2004-11-25 |
| 修稿时间： | 2004-11-25 |
Research on Solubility of Solid Dispersions of Liposoluble Extract from Radix isatidis |
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| Authors: | WANG Lu-Lu ZHENG Wen-Sheng |
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| Abstract: | Solid dispersions of liposoluble extract from Radix isatidis were prepared with PVP K30, PEG 6000 and poloxamer 188 as hydrophilic carriers, respectively. A HPLC method was established for the determination of indirubin to study the solubilities of solid dispersions, using indirubin as a reference substance. The results showed that the solubilities of liposoluble extract in solid dispersions were considerably enhanced, decreased as time went on. The solid dispersions with PVP had the slowest decreasing rate. |
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| Keywords: | Radix isatidis solid dispersion indirubin solubility HPLC |
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