| 益气补血、活血解毒法治疗大动脉炎血管内皮损伤的免疫研究 |
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| 引用本文： | 刘冼宜,王振宇,闻颖.益气补血、活血解毒法治疗大动脉炎血管内皮损伤的免疫研究[J].中国中医药信息杂志,2011,18(2):11-13. |
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| 作者姓名： | 刘冼宜 王振宇 闻颖 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院中医科,黑龙江,哈尔滨,150086
2. 哈尔滨医科大学公共卫生学院营养与食品卫生学教研室,黑龙江,哈尔滨,150086 |
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| 基金项目： | 黑龙江省教育厅指导项目 |
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| 摘 要： | 目的观察益气补血、活血解毒法对大动脉炎血管内皮损伤的影响。方法将40例活动期大动脉炎患者随机分为中西医结合治疗组（复脉饮＋常规西药）和对照组（常规西药），治疗24周后观察临床疗效，并检测治疗前和治疗后第4、24周血管内皮生长因子（VEGF）、内皮素-1（ET-1）、血管紧张素II（AngII）、循环内皮细胞（CECs）水平和数量变化。结果中西医结合治疗组疗效优于对照组，治疗组治疗4周、24周后VEGF、ET-1、AngII下降优于对照组（P〈0．05），治疗组治疗4周后CECs下降优于对照组（P〈0．05）。结论中西医结合治疗可提高大动脉炎的疗效，改善血管内皮损伤。
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| 关 键 词： | 大动脉炎 益气补血 活血解毒 血管内皮损伤 |
Immunity Research of Yiqi Buxue and Huoxue Jiedu Method on Vascular Endothelial Injury in Patients with Takayasu's Arteritis |
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| LIU Xian-yi,WANG Zhen-yu,WEN Ying.Immunity Research of Yiqi Buxue and Huoxue Jiedu Method on Vascular Endothelial Injury in Patients with Takayasu's Arteritis[J].Chinese Journal of Information on Traditional Chinese Medicine,2011,18(2):11-13. |
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| Authors: | LIU Xian-yi WANG Zhen-yu WEN Ying |
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| Institution: | LIU Xian-yi1,WANG Zhen-yu1,WEN Ying2(1.Department of Traditional Chinese Medicine,the Second Hospital Affiliated to Harbin Medical University,Harbin 150086,China,2.Department of Nutrition and Food Hygien,Public Health College,Harbin Medical University,China) |
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| Abstract: | Objective To observe the effect of Yiqi Buxue and Huoxue Jiedu method on vascular endothelial injury in patients with Takayasu＇s arteritis. Methods Forty patients with active Takayasu＇s arteritis were divided into combined treatment group （treated with traditional Chinese medicine Fumaiyin and western medicine） and control group （treated with western medicine）. Before treatment and after 4, 24 week＇s treatment, clinical effect was observed and the levels and quantity of VEGF, ET-1, AngIIand CECs were detected and compared. Results The combined treatment group showed a better clinical effect than control group. The serum VEGF, ET-1, Ang II levels of treatment group were significantly decreased compared with control group after 4, 24 week＇s treatment （P〈0.05）. The quantity of CECs of combined treatment group was significantly decreased compared with control group after 4 week＇s treatment （P 〈 0.05）. Conclusion Combined treatment of traditional Chinese medicine and western medicine can improve clinical effect and vascular endothelial injury of Takayasu＇s arteritis patients. |
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| Keywords: | Takayasu's arteritis Yiqi Buxue Huoxue Jiedu vascular endothelial injury |
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