Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin

Authors:	Mochizuki Hideki Kimura Yuichi Ishii Kenji Oda Keiichi Sasaki Toru Tashiro Manabu Yanai Kazuhiko Ishiwata Kiichi

Affiliation:	^aDepartment of Pharmacology, Tohoku University School of Medicine, Sendai, 980-8575, Japan ^bPositron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0022, Japan

Abstract:	The aim of this study was to develop simplified positron emission tomography measurement using [¹¹C]doxepin ([¹¹C]DOX) to evaluate histamine H₁ receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [¹¹C]DOX, estimated quantitatively with a two-compartment model, and the [¹¹C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [¹¹C]DOX–H1R binding.

Keywords:	Histamine H₁ receptor [¹¹C]Doxepin Static PET scanning
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