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| Nm23-H1基因表达与非小细胞肺癌转移的关系 | |
| 引用本文： | 孙莉,韩军,姚俊涛,苗青,任小平,任亚娟,张华丽. Nm23-H1基因表达与非小细胞肺癌转移的关系[J]. 现代肿瘤医学, 2001, 9(3): 152-154 |
| 作者姓名： | 孙莉 韩军 姚俊涛 苗青 任小平 任亚娟 张华丽 |
| 作者单位： | 1. 陕西省人民医院老年呼吸科, 2. 陕西省肿瘤医院, |
| 摘 要： | 目的探讨nm23-H1基因表达与非小细胞肺癌(NSCLC)转移的关系.方法应用免疫组织化学SABC方法对90例NSCLC组织标本进行nm23-H1表达的检测.结果 NSCLC的nm23-H1阳性表达率51.1%(46/90),和NSCLC不同组织学类型、病理分级、PTNM分期、性别、年龄及远处转移无关(P＞0.05);nm23-H1的阳性表达与淋巴结转移呈负相关(P＜0.01),与NSCLC患者术后生存期呈正相关(P＜0.05).结论 nm23-H1可作为预测NSCLC淋巴结转移及预后的指标. |
| 关 键 词： | 非小细胞肺癌 免疫组织化学 nm23-H1 转移 |
| 文章编号： | 1008-7001(2001)03-0152-03 |
| 修稿时间： | 2000-12-15 |
The correlation between expression of nm23-H1 gene and metastasis of non-small cell lung cancer |
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| SUN LI,HAN Jun,YAO Jun-tao,et al.. The correlation between expression of nm23-H1 gene and metastasis of non-small cell lung cancer[J]. Journal of Modern Oncology, 2001, 9(3): 152-154 | |
| Authors: | SUN LI HAN Jun YAO Jun-tao et al. |
| Affiliation: | SUN LI1,HAN Jun2,YAO Jun-tao2,et al. 1 Department of Respiration,Shaanxi Province People's Hospital,Xi'an 710068,China 2 Shaanxi Province Cancer Hospital,Xi'an 710061,China |
| Abstract: | Objective To study the correlation between expression of nm23-H1 gene and metastasis of non-small cell lung cancer.Methods Using immunohistochemical staining SABC method, tissue sections from 90 cases with NSCLC were investigated for expression of nm23-H1.Results The positive expression rate of nm23-H1 was51.1%(46/90), and it had no relation with age, sex, histopathologic type and the metastasis of other organs (P>0.05), but had negative correlation with lymph node metastasis (P<0.01) and had positive correlation with the patient's survival time(P<0.05).Conclusion nm23-H1 is an important index to lymph node metastasis in NSCLC and prognosis. |
| Keywords: | non-small cell lung cancer immunohistochemistry nm23-H1 metastasis |
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