Pharmacokinetics of intravenously administered ciprofloxacin in intensive care patients with acute renal failure |
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| Authors: | M. S. C. Dirksen and T. B. Vree |
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| Affiliation: | (1) Department of Intensive Care, Sint Radboud Hospital, Catholic University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands;(2) Department of Anesthesiology, Sint Radboud Hospital, Catholic University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands |
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| Abstract: | The pharmacokinetics of ciprofloxacin after a single intravenous administration of 100 mg were studied in intensive care patients with an acute renal impairment. There was no correlation found between the creatinine clearance and the renal clearance of ciprofloxacin. This applies to the entire group of patients. The decrease in renal clearance of ciprofloxacin was, however, more pronounced than the change in the elimination half-life, suggesting an important extra-renal elimination of the drug. |
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| Keywords: | Ciprofloxacin Drug evaluation Intensive care Kidney failure, acute Pharmacokinetics Renal clearance |
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