右美托咪定的药物相互作用

背景 右美托咪定(dexmedetomidinne,Dex)是一种高选择性的α2肾上腺素能受体激动剂,兼具有镇静、镇痛、降低交感神经张力等作用,同时无呼吸抑制和脑电干扰等副作用,现已广泛应用于临床.大量研究表明Dex和麻醉药物之间存在药物相互作用. 目的 综述国内外Dex和麻醉药物在药代学和药效学上的相互作用研究,为临床合理应用提供参考. 内容 探讨Dex与麻醉药物之间相互作用所产生的临床效应,如减少麻醉药物用量、减少药物副作用的发生率、稳定血流动力学等,并探讨其发生的相关机制. 趋向 随着研究的不断深入,期望Dex能在临床应用中得到更广泛的应用.

Review of drug interactions between dexmedetomidine and other anesthetic agent

Background Dexmedetomidine (Dex) is an α2 adrenergic receptor agonist widely used clinically,exhibiting effects such as sedation,analgesia,and sympatholytic.Meanwhile,Dex causes no suppression on breathing and no disturbance on electroencephalograph.Many researches have shown that Dex interacts with other anesthetic agents.Objective This article aims to review both domestic and oversea studies on the pharmacokinetics and pharmacodynamics of the interactions between Dex and other anesthetic agents as to guide clinical applications of Dex.Content The review discusses the clinical effects of the interaction of Dex and other anesthetic agents,such as reduction in dosage of both agents,reduction in occurrence of adverse effects of both agents,and the stabilization of hemodynamics.The article then reviews the related mechanisms of each effect.Trend As more studies on Dex are carried out,the future of Dex is looking bright.