微环境中调节性T细胞与乳腺癌关系的研究进展

乳腺癌肿瘤免疫微环境是乳腺癌细胞与免疫细胞、免疫分子之间相互作用的场所,对乳腺癌的发生发展及预后产生重要影响.调节性T细胞(Tregs)作为一类具有免疫抑制功能的T淋巴细胞亚群,可通过抑制T细胞的功能,抑制机体抗肿瘤免疫,促进肿瘤的发生发展.研究显示,乳腺肿瘤免疫微环境中Tregs在乳腺癌发生、发展以及靶向治疗中发挥着重要作用.

Research advancements of relationship between regulatory T cells and breast cancer in tumor immune microenvironment

Breast tumor immune microenvironment is the place,in which breast cancer cells interact with immune cells and immune molecules,playing an important role on the development and prognosis of breast cancer.As a suppressive functional subset of T cells,regulatory T cells can suppress the activation of T cells and anti-tumor immune responses,promote tumor formation and development.This article briefly reviewed the relationship between regulatory T cells in the breast tumor immune microenvironment and breast cancer occurrence,development,metastasis and prognosis and Treg application.