| 葡萄糖转运蛋白-1与肺动脉高压相关性研究进展 |
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| 引用本文： | 孙青,马正良,李冰冰. 葡萄糖转运蛋白-1与肺动脉高压相关性研究进展[J]. 国际麻醉学与复苏杂志, 2016, 0(7): 658-662. DOI: 10.3760/cma.j.issn.1673-4378.2016.06.018 |
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| 作者姓名： | 孙青 马正良 李冰冰 |
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| 作者单位： | 南京大学医学院附属鼓楼医院麻醉科,210008 |
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| 基金项目： | 国家自然科学基金青年科学基金(30901406;C160203),江苏省自然科学基金面上项目(BK2012532)National Natural Science Foundation of China(30901406 |
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| 摘 要： | 背景 肺动脉高压(pulmonary arterial hypertension,PAH)是一种常见的全身性疾病.研究发现PAH患者损伤部位的肺动脉平滑肌细胞伴有能量代谢异常,葡萄糖转运蛋白(glucose transporter,GLUT)-1异常高表达. 目的 探讨GLUT-1在PAH中的研究进展,为治疗PAH提供新的治疗策略. 内容 介绍GLUT-1的特性,探讨其在PAH疾病中上调的机制.趋向 GLUT-1可能成为治疗PAH的新靶点,为PAH的治疗提供新方向.
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| 关 键 词： | 肺动脉高压 葡萄糖转运蛋白-1 |
Review of current researches on glucose transporter-1 in correlation with pulmonary hypertension |
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| Abstract: | Backgroud Pulmonary arterial hypertension (PAH) is a common systemic disease.The study found the site of injury in patients with PAH associated with pulmonary vascular smooth muscle cell energy metabolism,glucose transporter (GLUT)-1 abnormally high expression.Objective The aim of this review is to discuss the role of GLUT-1 in PAH,provide new therapeutic strategies for the treatment of PAH.Content At first,the characteristics of GLUT-1 were introduced.Secondly,we explored the mechanism of disease increases in PAH.Trend GLUT-1 may be a new target for the treatment of PAH,providing new directions for the treatment of PAH. |
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| Keywords: | Pulmonary arterial hypertension Glucose transporter-1 |
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