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| 糖尿病患者测定视黄醇结合蛋白4和胱抑素C的意义 | |
| 引用本文： | 刘琰,郝潇蕾,吴悦,常东. 糖尿病患者测定视黄醇结合蛋白4和胱抑素C的意义[J]. 实用医学杂志, 2011, 27(17). DOI: 10.3969/j.issn.1006-5725.2011.17.055 |
| 作者姓名： | 刘琰 郝潇蕾 吴悦 常东 |
| 作者单位： | 1. 哈尔滨医科大学附属第一医院检验科,150001 2. 哈尔滨市第一医院检验科,150002 |
| 基金项目： | 黑龙江省自然科学基金项目 |
| 摘 要： | 目的:探讨多指标[血清胱抑素C(Cys C),视黄醇结合蛋白4(RBP4)和尿RBP4、微量白蛋白(mALB)]联合检测对糖尿病早期肾损害的I临床诊断价值.方法:采用病例对照研究,2型糖尿病患者155例(糖尿病组),对照组155例.比浊法检测血清cys C、RBP4,尿mALB和尿RBP4含量.结果:糖尿病患者血清Cys C、RBP4、尿mALB和尿RBP4含量均比对照组有显著升高(P<0.01),多指标联用后以Cys C+尿mALB检出率最高,为30.3%,其次为尿mALB+尿RBP4,为28.4%,三指标联用(Cys C+血RBP4+尿mALB、血RBP4+尿mALB+尿RBP4)检出率都是32.3%,与两指标检测没有明显差异,但多指标联用较单指标检出阳性率显著提高(P<0.05).结论:糖尿病患者应定期监测其肾功能损害程度,适当选择多指标联合检测可有效提高检出率. |
| 关 键 词： | 糖尿病 胱抑素C 视黄醇结合蛋白 尿微量白蛋白 |
Detection of Retinal-binding Protein 4 and Cystatin C in patients with diabetes |
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| LIU Yan,HAO Xiao-Lei,WU Yue,CHANG Dong. Detection of Retinal-binding Protein 4 and Cystatin C in patients with diabetes[J]. The Journal of Practical Medicine, 2011, 27(17). DOI: 10.3969/j.issn.1006-5725.2011.17.055 | |
| Authors: | LIU Yan HAO Xiao-Lei WU Yue CHANG Dong |
| Abstract: | Objective Discussion on the clinical diagnostic value of joint detection with multi-index (including serum Cys C, serum RBP4, urinary mALB and urinary RBP4)in early diabetic renal damage to improve the detection rate of renal damage. Method Case control study was used and 155 cases with type 2 diabetes in treatment group and 155 healthy cases in control group. Turbidimetry was used to test content of serum Cys C, serum RBP4, urinary mALB and urinary RBP4. Results Serum Cys C, serum RBP4, urinary mALB and ur... |
| Keywords: | Diabetes mellitus Cystatin C Retinol binding protein Urinary microalbumin |
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