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Nasal dermal sinus cysts with intracranial extension in a child mosaic for a supernumerary ring chromosome 20
Authors:Bernarda Lozić  Draško Cikojević  Vlatko Ledenko  Marisa Klančnik  Ružica Lasan  Tatijana Zemunik
Affiliation:1. Department of Pediatrics, University Hospital Split, Spin?i?eva 1, 21000 Split, Croatia;2. Department of Othorinolaringology, University Hospital Split, Spin?i?eva 1, 21000 Split, Croatia;3. Department of Neurosurgery, University Hospital Split, Spin?i?eva 1, 21000 Split, Croatia;4. Department of Pediatrics, Clinical Hospital Centre Zagreb, Ki?pati?eva 12, 10000 Zagreb, Croatia;5. Department of Medical Biology, University of Split, School of Medicine, ?oltanska 2, 21000 Split, Croatia;1. Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan;2. Department of Surgical Pathology, University of Occupational and Environmental Health, Kitakyushu, Japan;1. Attending Surgeon, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;2. Resident, Department of Endodontics, School of Stomatology, Shandong University, Jinan, China;3. Resident, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;4. Attending Surgeon, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;6. Attending Surgeon, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;5. Professor and Chairman, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;1. Warwick Dentistry, Warwick Medical School, University of Warwick, Coventry, UK;2. Children''s Hospital Los Angeles, Los Angeles, CA, USA;3. Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA;4. Department of Pediatrics, Children''s Hospital Los Angeles, Los Angeles, CA, USA;5. Division of Plastic and Maxillofacial Surgery, Children’s Hospital Los Angeles, Los Angeles, CA, USA;1. Department of Cranio-Maxillo-Facial Surgery of the pediatric hospital, hôpital Femme-Mère-Enfant, 59, boulevard Pinel, 69677 Bron, France;2. Université Claude-Bernard Lyon 1, 43, boulevard du 11 Novembre 1918, 69100 Villeurbanne, France;3. INSERM, National Institute of Health and Medical Research, Unit 1032, 151, Cours Albert-Thomas, 69424 Lyon cedex 03, France;1. Oral and Maxillofacial Surgery, Maxillofacial and Regional Cleft Centre, Teaching Hospital, Karapitiya, Galle, Sri Lanka;2. Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka
Abstract:Nasal dermal sinus cysts are congenital malformations that result from anomalous embryological development and are not prescribed to any specific genetic defect. The occurrence of a supernumerary ring 20 that causes a partial trisomy 20 mosaicism is a rare chromosome abnormality and no common phenotype has been described yet. We present a unique case of a 3.5-year-old child with a supernumerary ring chromosome 20 mosaicism associated with nasal dermoid with intracranial extension. It is possible that this genetic defect contribute to embryonic developmental errors of the frontonasal region. The clinical presentation, surgical treatment, and literature review of this case are discussed.
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