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| 怀菊花茎叶中一个新聚炔类化合物 | |
| 引用本文： | 石静亚,李孟,曾梦楠,张靖柯,刘娟娟,朱登辉,郑晓珂,冯卫生. 怀菊花茎叶中一个新聚炔类化合物[J]. 药学学报, 2021, 0(1): 283-288 |
| 作者姓名： | 石静亚 李孟 曾梦楠 张靖柯 刘娟娟 朱登辉 郑晓珂 冯卫生 |
| 作者单位： | 河南中医药大学药学院;河南省中药开发工程技术研究中心 |
| 基金项目： | 河南省重大科技专项(171100310500);国家重点研发计划-中医药现代化研究(2019YFC1708802);河南省高层次人才特殊支持计划“中原千人计划”-中原领军人才(ZYQR2018100). |
| 摘 要： | 采用多种色谱技术从怀菊花茎叶中分离得到8个聚炔类化合物。通过UV、IR、ESI-MS、HR-ESI-MS及NMR等波谱技术对其进行结构鉴定,分别为菊花新炔C (2E,4E,12Z-十四碳三烯-1-吡咯烷基-1-酮-8,10-二炔)(1)、tetradeca-2E, 4E, 12E-trien-8, 10-diynoic acid pyrrolidide (2)、tetradeca-2E, 4E-dien-8, 10-diynoic acid pyrrolidide (3)、tetradeca-2E,4E,10Z-trien-8-ynoic acid pyrrolidide (4)、2E,4E,12E-tetradecatriene-8,10-diynoic acid isobutylamide (5)、2E,4E-undecyldiene-8,10-diynoic acid isobutylamide (6)、2E,4E,10E-N-isobutyl-2,4,10-tetradecatrien-8-ynoic acid amide(7)和十一-2E,4E-二烯-8,10-二炔酸苯乙胺(... |
| 关 键 词： | 菊花 茎叶 化学成分 聚炔 细胞毒活性 |
A new polyacetylene from the stems and leaves of Chrysanthemum morifolium Ramat |
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| SHI Jing-ya,LI Meng,ZENG Meng-nan,ZHANG Jing-ke,LIU Juan-juan,ZHU Deng-hui,ZHENG Xiao-ke,FENG Wei-sheng. A new polyacetylene from the stems and leaves of Chrysanthemum morifolium Ramat[J]. Acta pharmaceutica Sinica, 2021, 0(1): 283-288 | |
| Authors: | SHI Jing-ya LI Meng ZENG Meng-nan ZHANG Jing-ke LIU Juan-juan ZHU Deng-hui ZHENG Xiao-ke FENG Wei-sheng |
| Affiliation: | (College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China) |
| Abstract: | Eight polyacetylenes were isolated from the extract of the stems and leaves of Chrysanthemum morifolium by various chromatographic methods.Their structures were determined as 2E,4E,12Z-tetradecatriene-1-pyrrolidine-1-oxo-8,10-diynoic(1),tetradeca-2E,4E,12E-trien-8,10-diynoic acid pyrrolidide(2),tetradeca-2E,4Edien-8,10-diynoic acid pyrrolidide(3),tetradeca-2E,4E,10Z-trien-8-ynoic acid pyrrolidide(4),2E,4E,12E-tetra‐decatriene-8,10-diynoic acid isobutylamide(5),2E,4E-undecyldiene-8,10-diynoic acid isobutylamide(6),2E,4E,10E-N-isobutyl-2,4,10-tetradecatrien-8-ynoic acid amide(7),and undeca-2E,4E-diene-8,10-diynoic acid phenyle‐thylamide(8)by spectroscopic methods,including UV,IR,ESI-MS,HR-ESI-MS,1D and 2D NMR spectra.Among them,compound 1 is a new polyacetylene,and compounds 2-8 were isolated from this plant for the first time.Compounds 5-8 inhibited the proliferation of A549 cell significantly at certain concentration,showing potent antitumor activity. |
| Keywords: | Chrysanthemum morifolium stem and leave chemical constituent polyacetylenes cytotoxicity |
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