| 高效液相色谱法测定利福定尿药浓度及生物利用度 |
| |
| 引用本文： | 何仲贵,唐星,蔡玉珉.高效液相色谱法测定利福定尿药浓度及生物利用度[J].沈阳药科大学学报,1992(1). |
| |
| 作者姓名： | 何仲贵 唐星 蔡玉珉 |
| |
| 作者单位： | 沈阳药学院药剂教研室，沈阳药学院药剂教研室，沈阳药学院药剂教研室 |
| |
| 摘 要： | 本文用反相高效液相色谱法测定了利福定在人体尿液中的浓度。色谱条件为:Shimpack CLC-TMS 5μm柱(150×4.6mm);0.01M磷酸二氢钾缓冲液—乙腈(50:50)为流动相;检测波长316nm.尿中利福定在0.2～20μg/ml的范围内呈线性关系。有机溶媒提取率为93%.用本法测定了利福定固体分散物相对于原药的生物利用度为147.7%.
|
| 关 键 词： | 高效液相色谱法 利福定 生物利用度 |
HPLC-DETERMINATION OF RIFANDIN CONTENT IN URINE AND ITS BIOAVILABILITY |
| |
| He Zhonggu.HPLC-DETERMINATION OF RIFANDIN CONTENT IN URINE AND ITS BIOAVILABILITY[J].Journal of Shenyang Pharmaceutical University,1992(1). |
| |
| Authors: | He Zhonggu |
| |
| Abstract: | A Rp-HPLC method has been developed for the quantitative determination of rifandin in urine. The chromatographic conditions were: a Shimpack CLC-TMS column (150×4.6mm),0.01M KH_2PO_4-Acetonitrile(50:50) as the mobile phase, 316nm of wave lengh. Good linear range was 0.5～20μg/ml. Extration ratio was 93%. The Bioavailability of rifandin dispersion against the original drug was 147.7%. |
| |
| Keywords: | Rifandin HPLC Bioavailability |
| 本文献已被 CNKI 等数据库收录！ |
