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| 戊型肝炎的病原学及流行病学研究 | |
| 引用本文： | 庄辉,刘崇柏,曹学义,王光明. 戊型肝炎的病原学及流行病学研究[J]. 北京大学学报(医学版), 1992, 0(4) |
| 作者姓名： | 庄辉 刘崇柏 曹学义 王光明 |
| 作者单位： | 北京医科大学公共卫生学院(庄辉)，中国预防医学科学院病毒研究所(刘崇柏)，新疆维吾尔自治区卫生防疫站(曹学义)，中国医学科学院实验动物研究所(王光明) |
| 摘 要： | 本文对我国戊型肝炎的流行病学、病原学、动物实验感染、临床、组织病理学及预防进行了研究。戊型肝炎主要侵犯青壮年;儿童和老人发病较少;男性多于女性;主要经污染的水和食物传播。从戊型肝炎病人和实验感染HEV猕猴粪便中检测到HEV并获得HEV cDNA克隆。中国和缅甸株HEV核甙酸和氨基酸的同源性分别为94.3％和99.6％。对562例戊型肝炎病人的临床特点和7例黄疸型成型肝炎病人的肝活检组织病理学改变进行了分析。随机双盲对照试验证明,血清免疫球蛋白对控制戊型肝炎无效。 |
| 关 键 词： | 戊型肝炎 成型肝炎病毒 动物模型 血清免疫球蛋白 |
STUDT ON ETIOLOGY AND EPIDEMIOLOGY OF HEPATITIS E |
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| Zhuang Hui,et al. STUDT ON ETIOLOGY AND EPIDEMIOLOGY OF HEPATITIS E[J]. Journal of Peking University. Health sciences, 1992, 0(4) | |
| Authors: | Zhuang Hui et al |
| Affiliation: | Zhuang Hui,et al Department of Epidemiology,School of Public Health |
| Abstract: | The epidemiology, etiology, animal experimental transmission, clinical features, histopathology andprevention of hepatitis E in China were studied. Hepatitis E mainly affects young adults, with fewercases in children and the elderly, and has a relative male excess of cases. The disease is more oftentransmitted through contaminated water and food. Hepatitis E virus (HEV) was detected in the stoolsof patients with hepatitis E and monkeys transmitted with HEV, and HEV cNDA clones were obtained.The homology of nucleotides and amino acids between Chinese and Myanmar strains were 94.3% and99.6%, respectively. The clinical features of 562 patients with hepatitis E and histopathological changes in liver biopsies of 7 icteric patients were analyzed. A randomized double-blind and controlledstudy showed no effects of immune serum globulin (ISG) in the control of hepatitis E. |
| Keywords: | Hepatitis E Hepatitis E virus Animal model Immune serum globulin |
| 本文献已被 CNKI 等数据库收录！ | |