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| 牛初乳冻干粉对酒精性肝损伤的预防作用 | |
| 引用本文： | 吴京燕,潘玉英,杨云峰,蒋新陵,郁桦. 牛初乳冻干粉对酒精性肝损伤的预防作用[J]. 中国比较医学杂志, 2007, 17(1): 33-35,F0003 |
| 作者姓名： | 吴京燕 潘玉英 杨云峰 蒋新陵 郁桦 |
| 作者单位： | 1. 南京师范大学生命科学院,南京,210097;江苏吴中大自然生物工程有限责任公司,南京,210097 2. 江苏省药物研究所,南京,210008 3. 江苏吴中大自然生物工程有限责任公司,南京,210097 |
| 摘 要： | 目的研究牛初乳冻干粉对预防酒精肝损伤的作用。方法受试组灌胃牛初乳冻干粉（350mg／kg）30d，第30天时，与模型组同时灌胃50％乙醇（12mL／kg），对照组灌胃等量的蒸馏水，且不服用酒精，禁食12h后处死小鼠。取左叶肝测试生化指标，并取样固定后制作肝病理切片。结果受试组与酒精模型组谷胱甘肽（GSH）、高密度脂蛋白胆固醇（HDLc）提高，差异显著（P＜0．05与P＜0．01），但受试组甘油三酯（TG）较模型组高，有待研究。肝病理切片显示模型组肝脂肪变性损伤评分值较对照组高达4．5倍，而牛初乳冻干粉受试组与对照组评分值相似。结论牛初乳冻干粉具有预防酒精肝损伤的效果。 |
| 关 键 词： | 牛初乳冻干粉 酒精 酒精性肝损伤 |
| 文章编号： | 1671-7856（2007）01-0033-03 |
| 收稿时间： | 2006-02-09 |
| 修稿时间： | 2006-02-09 |
The Defend Function of Lyophilized Bovine Colostrums on Alcohol Liver Injury in Mice |
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| WU Jing-yan,PAN Yu-ying,YANG Yun-feng,JIANG Xin-ling,YU Hua. The Defend Function of Lyophilized Bovine Colostrums on Alcohol Liver Injury in Mice[J]. Chinese Journal of Comparative Medicine, 2007, 17(1): 33-35,F0003 | |
| Authors: | WU Jing-yan PAN Yu-ying YANG Yun-feng JIANG Xin-ling YU Hua |
| Abstract: | Objective To study the defend function of lyophilized bovine colostrums on alcohol liver injury in mice.Methods Objective Lyophilized Bovine Colostrums(350 mg/kg) 3 d.The alcohol model group also used 50% alcohol(12 mL/kg) together.The control group only used distilled water.The experiment tested biochemistry and alcohol liver injury in adipose.Results The Lyophilized Bovine Colostrums group and alcohol model group GSH,HDL-C increased significant and deceased The content of MDA,Its protect effect was also proved by liver patholgical changes in total score.Conclusion Lyophilized Bovine Colostrums had protectived effect on alcohol liver injury. |
| Keywords: | Lyophilized Bovine Colostrums Alcohol Alcohol Liver Injury. |
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